Risk factors of dermatitis during radiation for vulvar carcinoma
Abstract Radiodermatitis, inflammatory lesions of skin and mucosa caused by radiation, is a common adverse effect during the radiation therapy of vulvar carcinoma. The incidence of radiodermatitis is affected by various factors, and the purpose of this study was to investigate the risk factors of ra...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Precision Medical Sciences |
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| Online Access: | https://doi.org/10.1002/prm2.12077 |
| _version_ | 1798035244236931072 |
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| author | Xue Teng Xian Zhang Xiaoxu Zhi Yan Chen Dejing Xu Aifeng Meng Ying Zhu |
| author_facet | Xue Teng Xian Zhang Xiaoxu Zhi Yan Chen Dejing Xu Aifeng Meng Ying Zhu |
| author_sort | Xue Teng |
| collection | DOAJ |
| description | Abstract Radiodermatitis, inflammatory lesions of skin and mucosa caused by radiation, is a common adverse effect during the radiation therapy of vulvar carcinoma. The incidence of radiodermatitis is affected by various factors, and the purpose of this study was to investigate the risk factors of radiodermatitis in patients with vulvar carcinoma. Patients with vulvar tumors who received radiotherapy from January 2015 to December 2020 were included in this retrospective study. Radiodermatitis was graded according to the grading criteria of the American Center for Radiological Oncology, and then univariate analysis and logistic multivariate regression analysis were used to determine the risk factors of radiodermatitis. A total of 60 eligible patients were enrolled, including 3 (5%), 25 (41.7%), 28 (46.7%), and 4 (6.6%) patients with grade 0, 1, 2, and 3 radiodermatitis, respectively. Univariate analysis showed that the incidence of radiodermatitis was significantly correlated with age, therapeutic strategy, pathological stage and radiotherapy dose (p < .05). Multivariate regression analysis indicated that age, therapeutic strategy and radiotherapy dose were independent risk factors for radiodermatitis (p < .05). In the current study, we identified the independent risk factors for radiodermatitis in patients with vulvar carcinoma were age, therapeutic strategy and radiotherapy dose, which might be conducive to identify high‐risk patients, so as to adjust their treatment plan in time and reduce the risk of radiation‐induced skin toxicity. |
| first_indexed | 2024-04-11T20:55:31Z |
| format | Article |
| id | doaj.art-4855f35246b346c2b346fb9d89a51931 |
| institution | Directory Open Access Journal |
| issn | 2642-2514 |
| language | English |
| last_indexed | 2024-04-11T20:55:31Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Medical Sciences |
| spelling | doaj.art-4855f35246b346c2b346fb9d89a519312022-12-22T04:03:41ZengWileyPrecision Medical Sciences2642-25142022-09-0111310611010.1002/prm2.12077Risk factors of dermatitis during radiation for vulvar carcinomaXue Teng0Xian Zhang1Xiaoxu Zhi2Yan Chen3Dejing Xu4Aifeng Meng5Ying Zhu6Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaDepartment of Radiation Oncology The Affiliated Hospital of Xuzhou Medical University Xuzhou ChinaJiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaJiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaJiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaJiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaJiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaAbstract Radiodermatitis, inflammatory lesions of skin and mucosa caused by radiation, is a common adverse effect during the radiation therapy of vulvar carcinoma. The incidence of radiodermatitis is affected by various factors, and the purpose of this study was to investigate the risk factors of radiodermatitis in patients with vulvar carcinoma. Patients with vulvar tumors who received radiotherapy from January 2015 to December 2020 were included in this retrospective study. Radiodermatitis was graded according to the grading criteria of the American Center for Radiological Oncology, and then univariate analysis and logistic multivariate regression analysis were used to determine the risk factors of radiodermatitis. A total of 60 eligible patients were enrolled, including 3 (5%), 25 (41.7%), 28 (46.7%), and 4 (6.6%) patients with grade 0, 1, 2, and 3 radiodermatitis, respectively. Univariate analysis showed that the incidence of radiodermatitis was significantly correlated with age, therapeutic strategy, pathological stage and radiotherapy dose (p < .05). Multivariate regression analysis indicated that age, therapeutic strategy and radiotherapy dose were independent risk factors for radiodermatitis (p < .05). In the current study, we identified the independent risk factors for radiodermatitis in patients with vulvar carcinoma were age, therapeutic strategy and radiotherapy dose, which might be conducive to identify high‐risk patients, so as to adjust their treatment plan in time and reduce the risk of radiation‐induced skin toxicity.https://doi.org/10.1002/prm2.12077radiodermatitisrisk factorsvulvar carcinoma |
| spellingShingle | Xue Teng Xian Zhang Xiaoxu Zhi Yan Chen Dejing Xu Aifeng Meng Ying Zhu Risk factors of dermatitis during radiation for vulvar carcinoma Precision Medical Sciences radiodermatitis risk factors vulvar carcinoma |
| title | Risk factors of dermatitis during radiation for vulvar carcinoma |
| title_full | Risk factors of dermatitis during radiation for vulvar carcinoma |
| title_fullStr | Risk factors of dermatitis during radiation for vulvar carcinoma |
| title_full_unstemmed | Risk factors of dermatitis during radiation for vulvar carcinoma |
| title_short | Risk factors of dermatitis during radiation for vulvar carcinoma |
| title_sort | risk factors of dermatitis during radiation for vulvar carcinoma |
| topic | radiodermatitis risk factors vulvar carcinoma |
| url | https://doi.org/10.1002/prm2.12077 |
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