Successful ECMO treatment in patients with cerebral hemorrhage and PROC gene mutation associated with VTE: a case report
Abstract In this report, we report a case of a middle-aged male, admitted to the ICU with cerebral hemorrhage resulting from a severe high-altitude fall. The patient encountered significant challenges in oxygenation index correction, attributed to extensive embolism in both the primary and branch pu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12959-024-00601-y |
| _version_ | 1797209128160985088 |
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| author | Lijie Wang Chengyong Ma Luping Wang Qianrong Ding Hao Yang Bo Wang Qin Wu |
| author_facet | Lijie Wang Chengyong Ma Luping Wang Qianrong Ding Hao Yang Bo Wang Qin Wu |
| author_sort | Lijie Wang |
| collection | DOAJ |
| description | Abstract In this report, we report a case of a middle-aged male, admitted to the ICU with cerebral hemorrhage resulting from a severe high-altitude fall. The patient encountered significant challenges in oxygenation index correction, attributed to extensive embolism in both the primary and branch pulmonary arteries. Consequently, the patient underwent an immediate initiation of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) therapy, persisting for 20 days. During this treatment period, a mutation in the protein C (PROC) gene was identified. The medical team meticulously navigated the delicate balance between anticoagulation and bleeding risks. Eventually, the patient was successfully weaned off VA-ECMO and subsequently discharged. This report aims to delve into the etiology and therapeutic approaches of this uncommon case, with the intention of offering insightful reference for managing similar clinical scenarios in the future. |
| first_indexed | 2024-04-24T09:49:46Z |
| format | Article |
| id | doaj.art-48577d8dc19f4276a9424d7973ad4701 |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-04-24T09:49:46Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-48577d8dc19f4276a9424d7973ad47012024-04-14T11:25:38ZengBMCThrombosis Journal1477-95602024-04-012211710.1186/s12959-024-00601-ySuccessful ECMO treatment in patients with cerebral hemorrhage and PROC gene mutation associated with VTE: a case reportLijie Wang0Chengyong Ma1Luping Wang2Qianrong Ding3Hao Yang4Bo Wang5Qin Wu6Department of Critical Care Medicine, West China Hospital of Sichuan University, Sichuan ProvinceDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Sichuan ProvinceDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Sichuan ProvinceDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Sichuan ProvinceDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Sichuan ProvinceDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Sichuan ProvinceDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Sichuan ProvinceAbstract In this report, we report a case of a middle-aged male, admitted to the ICU with cerebral hemorrhage resulting from a severe high-altitude fall. The patient encountered significant challenges in oxygenation index correction, attributed to extensive embolism in both the primary and branch pulmonary arteries. Consequently, the patient underwent an immediate initiation of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) therapy, persisting for 20 days. During this treatment period, a mutation in the protein C (PROC) gene was identified. The medical team meticulously navigated the delicate balance between anticoagulation and bleeding risks. Eventually, the patient was successfully weaned off VA-ECMO and subsequently discharged. This report aims to delve into the etiology and therapeutic approaches of this uncommon case, with the intention of offering insightful reference for managing similar clinical scenarios in the future.https://doi.org/10.1186/s12959-024-00601-yECMOAnticoagulationPROCVTEPulmonary Embolism |
| spellingShingle | Lijie Wang Chengyong Ma Luping Wang Qianrong Ding Hao Yang Bo Wang Qin Wu Successful ECMO treatment in patients with cerebral hemorrhage and PROC gene mutation associated with VTE: a case report Thrombosis Journal ECMO Anticoagulation PROC VTE Pulmonary Embolism |
| title | Successful ECMO treatment in patients with cerebral hemorrhage and PROC gene mutation associated with VTE: a case report |
| title_full | Successful ECMO treatment in patients with cerebral hemorrhage and PROC gene mutation associated with VTE: a case report |
| title_fullStr | Successful ECMO treatment in patients with cerebral hemorrhage and PROC gene mutation associated with VTE: a case report |
| title_full_unstemmed | Successful ECMO treatment in patients with cerebral hemorrhage and PROC gene mutation associated with VTE: a case report |
| title_short | Successful ECMO treatment in patients with cerebral hemorrhage and PROC gene mutation associated with VTE: a case report |
| title_sort | successful ecmo treatment in patients with cerebral hemorrhage and proc gene mutation associated with vte a case report |
| topic | ECMO Anticoagulation PROC VTE Pulmonary Embolism |
| url | https://doi.org/10.1186/s12959-024-00601-y |
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