Hydrogels for Engineering of Perfusable Vascular Networks
Hydrogels are commonly used biomaterials for tissue engineering. With their high-water content, good biocompatibility and biodegradability they resemble the natural extracellular environment and have been widely used as scaffolds for 3D cell culture and studies of cell biology. The possible size of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/16/7/15997 |
| _version_ | 1811312476352937984 |
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| author | Juan Liu Huaiyuan Zheng Patrina S. P. Poh Hans-Günther Machens Arndt F. Schilling |
| author_facet | Juan Liu Huaiyuan Zheng Patrina S. P. Poh Hans-Günther Machens Arndt F. Schilling |
| author_sort | Juan Liu |
| collection | DOAJ |
| description | Hydrogels are commonly used biomaterials for tissue engineering. With their high-water content, good biocompatibility and biodegradability they resemble the natural extracellular environment and have been widely used as scaffolds for 3D cell culture and studies of cell biology. The possible size of such hydrogel constructs with embedded cells is limited by the cellular demand for oxygen and nutrients. For the fabrication of large and complex tissue constructs, vascular structures become necessary within the hydrogels to supply the encapsulated cells. In this review, we discuss the types of hydrogels that are currently used for the fabrication of constructs with embedded vascular networks, the key properties of hydrogels needed for this purpose and current techniques to engineer perfusable vascular structures into these hydrogels. We then discuss directions for future research aimed at engineering of vascularized tissue for implantation. |
| first_indexed | 2024-04-13T10:37:59Z |
| format | Article |
| id | doaj.art-4858ea3e24364fd6987875e9c1c6e571 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T10:37:59Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4858ea3e24364fd6987875e9c1c6e5712022-12-22T02:50:00ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-07-01167159971601610.3390/ijms160715997ijms160715997Hydrogels for Engineering of Perfusable Vascular NetworksJuan Liu0Huaiyuan Zheng1Patrina S. P. Poh2Hans-Günther Machens3Arndt F. Schilling4Department of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, GermanyDepartment of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, GermanyDepartment of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, GermanyDepartment of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, GermanyDepartment of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, D-81675 Munich, GermanyHydrogels are commonly used biomaterials for tissue engineering. With their high-water content, good biocompatibility and biodegradability they resemble the natural extracellular environment and have been widely used as scaffolds for 3D cell culture and studies of cell biology. The possible size of such hydrogel constructs with embedded cells is limited by the cellular demand for oxygen and nutrients. For the fabrication of large and complex tissue constructs, vascular structures become necessary within the hydrogels to supply the encapsulated cells. In this review, we discuss the types of hydrogels that are currently used for the fabrication of constructs with embedded vascular networks, the key properties of hydrogels needed for this purpose and current techniques to engineer perfusable vascular structures into these hydrogels. We then discuss directions for future research aimed at engineering of vascularized tissue for implantation.http://www.mdpi.com/1422-0067/16/7/15997hydrogelsvascular networkstissue engineeringfabrication |
| spellingShingle | Juan Liu Huaiyuan Zheng Patrina S. P. Poh Hans-Günther Machens Arndt F. Schilling Hydrogels for Engineering of Perfusable Vascular Networks International Journal of Molecular Sciences hydrogels vascular networks tissue engineering fabrication |
| title | Hydrogels for Engineering of Perfusable Vascular Networks |
| title_full | Hydrogels for Engineering of Perfusable Vascular Networks |
| title_fullStr | Hydrogels for Engineering of Perfusable Vascular Networks |
| title_full_unstemmed | Hydrogels for Engineering of Perfusable Vascular Networks |
| title_short | Hydrogels for Engineering of Perfusable Vascular Networks |
| title_sort | hydrogels for engineering of perfusable vascular networks |
| topic | hydrogels vascular networks tissue engineering fabrication |
| url | http://www.mdpi.com/1422-0067/16/7/15997 |
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