Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhiza
CULLIN (CUL) proteins are E3 ubiquitin ligases that are involved in a wide variety of biological processes as well as in response to stress in plants. In Salvia miltiorrhiza, CUL genes have not been characterized and its role in plant development, stress response and secondary metabolite synthesis h...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Food Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927122001812 |
| _version_ | 1811202231024746496 |
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| author | Xiankui Gao Xiujuan Li Chengan Chen Can Wang Yuqi Fu ZiZhen Zheng Min Shi Xiaolong Hao Limei Zhao Minghua Qiu Guoyin Kai Wei Zhou |
| author_facet | Xiankui Gao Xiujuan Li Chengan Chen Can Wang Yuqi Fu ZiZhen Zheng Min Shi Xiaolong Hao Limei Zhao Minghua Qiu Guoyin Kai Wei Zhou |
| author_sort | Xiankui Gao |
| collection | DOAJ |
| description | CULLIN (CUL) proteins are E3 ubiquitin ligases that are involved in a wide variety of biological processes as well as in response to stress in plants. In Salvia miltiorrhiza, CUL genes have not been characterized and its role in plant development, stress response and secondary metabolite synthesis have not been studied. In this study, genome-wide analyses were performed to identify and to predict the structure and function of CUL of S. miltiorrhiza. Eight CUL genes were identified from the genome of S. miltiorrhiza. The CUL genes were clustered into four subgroups according to phylogenetic relationships. The CUL domain was highly conserved across the family of CUL genes. Analysis of cis-acting elements suggested that CUL genes might play important roles in a variety of biological processes, including abscission reaction acid (ABA) processing. To investigate this hypothesis, we treated hairy roots of S. miltiorrhiza with ABA. The expression of CUL genes varied obviously after ABA treatment. Co-expression network results indicated that three CUL genes might be involved in the biosynthesis of phenolic acid or tanshinone. In summary, the mining of the CUL genes in the whole genome of S. miltiorrhiza contribute novel information to the understanding of the CUL genes and its functional roles in plant secondary metabolites, growth and development. |
| first_indexed | 2024-04-12T02:35:25Z |
| format | Article |
| id | doaj.art-4859b4dfb2b14fdf8ea165e20006403a |
| institution | Directory Open Access Journal |
| issn | 2665-9271 |
| language | English |
| last_indexed | 2024-04-12T02:35:25Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Food Science |
| spelling | doaj.art-4859b4dfb2b14fdf8ea165e20006403a2022-12-22T03:51:35ZengElsevierCurrent Research in Food Science2665-92712022-01-01517601768Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhizaXiankui Gao0Xiujuan Li1Chengan Chen2Can Wang3Yuqi Fu4ZiZhen Zheng5Min Shi6Xiaolong Hao7Limei Zhao8Minghua Qiu9Guoyin Kai10Wei Zhou11Laboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR ChinaLaboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR ChinaLaboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR ChinaLaboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR ChinaLaboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR ChinaLaboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR ChinaLaboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR ChinaLaboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR ChinaLaboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR ChinaState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR ChinaLaboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR China; Corresponding author. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Gaoke Road, Fuyang district, Hangzhou, Zhejiang, 311402, PR China.Laboratory for Core Technology of TCM Quality Improvement and Transformation, School of Pharmaceutical Sciences, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 311402, PR China; Corresponding author. School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Gaoke Road, Fuyang district, Hangzhou, Zhejiang, 311402, PR China.CULLIN (CUL) proteins are E3 ubiquitin ligases that are involved in a wide variety of biological processes as well as in response to stress in plants. In Salvia miltiorrhiza, CUL genes have not been characterized and its role in plant development, stress response and secondary metabolite synthesis have not been studied. In this study, genome-wide analyses were performed to identify and to predict the structure and function of CUL of S. miltiorrhiza. Eight CUL genes were identified from the genome of S. miltiorrhiza. The CUL genes were clustered into four subgroups according to phylogenetic relationships. The CUL domain was highly conserved across the family of CUL genes. Analysis of cis-acting elements suggested that CUL genes might play important roles in a variety of biological processes, including abscission reaction acid (ABA) processing. To investigate this hypothesis, we treated hairy roots of S. miltiorrhiza with ABA. The expression of CUL genes varied obviously after ABA treatment. Co-expression network results indicated that three CUL genes might be involved in the biosynthesis of phenolic acid or tanshinone. In summary, the mining of the CUL genes in the whole genome of S. miltiorrhiza contribute novel information to the understanding of the CUL genes and its functional roles in plant secondary metabolites, growth and development.http://www.sciencedirect.com/science/article/pii/S2665927122001812Salvia miltiorrhizaGene familyExpression patternPhenolic acidTanshinoneCULLIN E3 ubiquitin ligase |
| spellingShingle | Xiankui Gao Xiujuan Li Chengan Chen Can Wang Yuqi Fu ZiZhen Zheng Min Shi Xiaolong Hao Limei Zhao Minghua Qiu Guoyin Kai Wei Zhou Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhiza Current Research in Food Science Salvia miltiorrhiza Gene family Expression pattern Phenolic acid Tanshinone CULLIN E3 ubiquitin ligase |
| title | Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhiza |
| title_full | Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhiza |
| title_fullStr | Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhiza |
| title_full_unstemmed | Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhiza |
| title_short | Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhiza |
| title_sort | mining of the cullin e3 ubiquitin ligase genes in the whole genome of salvia miltiorrhiza |
| topic | Salvia miltiorrhiza Gene family Expression pattern Phenolic acid Tanshinone CULLIN E3 ubiquitin ligase |
| url | http://www.sciencedirect.com/science/article/pii/S2665927122001812 |
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