Reproductive Counseling and Care in Cystic Fibrosis: A Multidisciplinary Approach for a New Therapeutic Era
With the advent of highly effective modulator therapies, many people with cystic fibrosis (CF) are living longer, healthier lives. Pregnancy rates for women with CF more than doubled between 2019 and 2021, reflecting increases in both planned and unplanned pregnancies. For men with CF, CF-associated...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/7/1545 |
| _version_ | 1797588554892705792 |
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| author | Julie McGlynn Joan K. DeCelie-Germana Catherine Kier Elinor Langfelder-Schwind |
| author_facet | Julie McGlynn Joan K. DeCelie-Germana Catherine Kier Elinor Langfelder-Schwind |
| author_sort | Julie McGlynn |
| collection | DOAJ |
| description | With the advent of highly effective modulator therapies, many people with cystic fibrosis (CF) are living longer, healthier lives. Pregnancy rates for women with CF more than doubled between 2019 and 2021, reflecting increases in both planned and unplanned pregnancies. For men with CF, CF-associated infertility can be mitigated with assistive reproductive technology, yet patient knowledge of these challenges and options is variable. Preconception and prenatal counseling for individuals with CF and for parents of children with CF who wish to expand their families requires nuanced discussions to promote informed reproductive decisions, drawing from a combination of standard practice recommendations and CF-specific assessments. This review article synthesizes the current literature and practice recommendations regarding reproductive counseling and care in CF, outlining the role of genetic counseling, carrier screening, teratogen counseling, in vitro fertilization and pre-implantation genetic diagnosis, and careful assessment and management of cystic fibrosis-related diabetes when present. Via a multidisciplinary, patient-centered approach, clinicians can support adults with CF and parents of children with CF as they make informed reproductive decisions and embark on family planning. |
| first_indexed | 2024-03-11T00:53:42Z |
| format | Article |
| id | doaj.art-485cef4266004cd6939061ed56670f4a |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T00:53:42Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-485cef4266004cd6939061ed56670f4a2023-11-18T20:09:59ZengMDPI AGLife2075-17292023-07-01137154510.3390/life13071545Reproductive Counseling and Care in Cystic Fibrosis: A Multidisciplinary Approach for a New Therapeutic EraJulie McGlynn0Joan K. DeCelie-Germana1Catherine Kier2Elinor Langfelder-Schwind3Gynecology and Reproductive Sciences, Department of Obstetrics, Yale School of Medicine, New Haven, CT 06510, USAZucker School of Medicine at Northwell Division of Pediatric Pulmonary, and Cystic Fibrosis Center, Cohen Children’s Medical Center, New Hyde Park, NY 11040, USARenaissance School of Medicine at Stony Brook, Department of Pediatrics, Stony Brook, NY 11794, USAThe Cystic Fibrosis Center, Department of Pulmonary Medicine, Lenox Hill Hospital, Northwell Health, New York, NY 10075, USAWith the advent of highly effective modulator therapies, many people with cystic fibrosis (CF) are living longer, healthier lives. Pregnancy rates for women with CF more than doubled between 2019 and 2021, reflecting increases in both planned and unplanned pregnancies. For men with CF, CF-associated infertility can be mitigated with assistive reproductive technology, yet patient knowledge of these challenges and options is variable. Preconception and prenatal counseling for individuals with CF and for parents of children with CF who wish to expand their families requires nuanced discussions to promote informed reproductive decisions, drawing from a combination of standard practice recommendations and CF-specific assessments. This review article synthesizes the current literature and practice recommendations regarding reproductive counseling and care in CF, outlining the role of genetic counseling, carrier screening, teratogen counseling, in vitro fertilization and pre-implantation genetic diagnosis, and careful assessment and management of cystic fibrosis-related diabetes when present. Via a multidisciplinary, patient-centered approach, clinicians can support adults with CF and parents of children with CF as they make informed reproductive decisions and embark on family planning.https://www.mdpi.com/2075-1729/13/7/1545cystic fibrosisfamily planningpregnancyfertilitygenetic counselinghighly effective modulators |
| spellingShingle | Julie McGlynn Joan K. DeCelie-Germana Catherine Kier Elinor Langfelder-Schwind Reproductive Counseling and Care in Cystic Fibrosis: A Multidisciplinary Approach for a New Therapeutic Era Life cystic fibrosis family planning pregnancy fertility genetic counseling highly effective modulators |
| title | Reproductive Counseling and Care in Cystic Fibrosis: A Multidisciplinary Approach for a New Therapeutic Era |
| title_full | Reproductive Counseling and Care in Cystic Fibrosis: A Multidisciplinary Approach for a New Therapeutic Era |
| title_fullStr | Reproductive Counseling and Care in Cystic Fibrosis: A Multidisciplinary Approach for a New Therapeutic Era |
| title_full_unstemmed | Reproductive Counseling and Care in Cystic Fibrosis: A Multidisciplinary Approach for a New Therapeutic Era |
| title_short | Reproductive Counseling and Care in Cystic Fibrosis: A Multidisciplinary Approach for a New Therapeutic Era |
| title_sort | reproductive counseling and care in cystic fibrosis a multidisciplinary approach for a new therapeutic era |
| topic | cystic fibrosis family planning pregnancy fertility genetic counseling highly effective modulators |
| url | https://www.mdpi.com/2075-1729/13/7/1545 |
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