A minimal human physiologically based kinetic model of thyroid hormones and chemical disruption of plasma thyroid hormone binding proteins

A minimal human physiologically based kinetic model of thyroid hormones and chemical disruption of plasma thyroid hormone binding proteins

The thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), are under homeostatic control by the hypothalamic-pituitary-thyroid axis and plasma TH binding proteins (THBPs), including thyroxine-binding globulin (TBG), transthyretin (TTR), and albumin (ALB). THBPs buffer free THs against tra...

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Bibliographic Details
Main Authors: Anish D. Bagga, Brian P. Johnson, Qiang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Endocrinology
Subjects:
thyroid hormone
thyroid hormone binding protein
thyroxine-binding globulin
transthyretin
albumin
PBK model
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1168663/full

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