Sex differences in antiplatelet therapy: state-of-the art
Antiplatelet therapy is a cornerstone of secondary prevention of cardiovascular diseases (CVDs). However, current guidelines are based on data derived primarily from men, as women are generally underrepresented in trials. Consequently, there are insufficient and inconsistent data on the effect of an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2023.2176173 |
| _version_ | 1797684127154044928 |
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| author | Aleksandra Gasecka Jakub M. Zimodro Yolande Appelman |
| author_facet | Aleksandra Gasecka Jakub M. Zimodro Yolande Appelman |
| author_sort | Aleksandra Gasecka |
| collection | DOAJ |
| description | Antiplatelet therapy is a cornerstone of secondary prevention of cardiovascular diseases (CVDs). However, current guidelines are based on data derived primarily from men, as women are generally underrepresented in trials. Consequently, there are insufficient and inconsistent data on the effect of antiplatelet drugs in women. Sex differences were reported in platelet reactivity, patient management, and clinical outcomes after treatment with aspirin, P2Y12 inhibitor, or dual antiplatelet therapy. To evaluate whether sex-specific antiplatelet therapy is needed, in this review we discuss (i) how sex affects platelet biology and response to antiplatelet agents, (ii) how sex and gender differences translate into clinical challenges and (iii) how the cardiological care in women might be improved. Finally, we highlight the challenges faced in clinical practice regarding the different needs and characteristics of female and male patients with CVD and address issues requiring further investigation. |
| first_indexed | 2024-03-12T00:25:00Z |
| format | Article |
| id | doaj.art-486363e1b6244dfbb810f3ffa52ac4bc |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:00Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-486363e1b6244dfbb810f3ffa52ac4bc2023-09-15T10:38:11ZengTaylor & Francis GroupPlatelets0953-71041369-16352023-12-0134110.1080/09537104.2023.21761732176173Sex differences in antiplatelet therapy: state-of-the artAleksandra Gasecka0Jakub M. Zimodro1Yolande Appelman2Medical University of Warsaw, Independent Public Central Teaching HospitalMedical University of Warsaw, Independent Public Central Teaching HospitalVU UniversityAntiplatelet therapy is a cornerstone of secondary prevention of cardiovascular diseases (CVDs). However, current guidelines are based on data derived primarily from men, as women are generally underrepresented in trials. Consequently, there are insufficient and inconsistent data on the effect of antiplatelet drugs in women. Sex differences were reported in platelet reactivity, patient management, and clinical outcomes after treatment with aspirin, P2Y12 inhibitor, or dual antiplatelet therapy. To evaluate whether sex-specific antiplatelet therapy is needed, in this review we discuss (i) how sex affects platelet biology and response to antiplatelet agents, (ii) how sex and gender differences translate into clinical challenges and (iii) how the cardiological care in women might be improved. Finally, we highlight the challenges faced in clinical practice regarding the different needs and characteristics of female and male patients with CVD and address issues requiring further investigation.http://dx.doi.org/10.1080/09537104.2023.2176173antiplatelet therapyaspiringenderp2y12inhibitorssex differenceswomen |
| spellingShingle | Aleksandra Gasecka Jakub M. Zimodro Yolande Appelman Sex differences in antiplatelet therapy: state-of-the art Platelets antiplatelet therapy aspirin gender p2y12inhibitors sex differences women |
| title | Sex differences in antiplatelet therapy: state-of-the art |
| title_full | Sex differences in antiplatelet therapy: state-of-the art |
| title_fullStr | Sex differences in antiplatelet therapy: state-of-the art |
| title_full_unstemmed | Sex differences in antiplatelet therapy: state-of-the art |
| title_short | Sex differences in antiplatelet therapy: state-of-the art |
| title_sort | sex differences in antiplatelet therapy state of the art |
| topic | antiplatelet therapy aspirin gender p2y12inhibitors sex differences women |
| url | http://dx.doi.org/10.1080/09537104.2023.2176173 |
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