Real-time quantification of the transmission advantage associated with a single mutation in pathogen genomes: a case study on the D614G substitution of SARS-CoV-2

Real-time quantification of the transmission advantage associated with a single mutation in pathogen genomes: a case study on the D614G substitution of SARS-CoV-2

Abstract Background The COVID-19 pandemic poses serious threats to global health, and the emerging mutation in SARS-CoV-2 genomes, e.g., the D614G substitution, is one of the major challenges of disease control. Characterizing the role of the mutation activities is of importance to understand how th...

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Bibliographic Details
Main Authors: Shi Zhao, Jingzhi Lou, Lirong Cao, Hong Zheng, Marc K. C. Chong, Zigui Chen, Renee W. Y. Chan, Benny C. Y. Zee, Paul K. S. Chan, Maggie H. Wang
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Infectious Diseases
Subjects:
COVID-19
Mutation
Transmission advantage
Real-time estimation
Statistical modelling
Online Access:https://doi.org/10.1186/s12879-021-06729-w

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