Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1

Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1

ABCA1 mediates the transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Apolipoprotein A-I (apoA-I) interactions with ABCA1-expressing cells elicit several responses, including removing cellular lipids, stabilizing ABCA1 protein, and activating Janus kinase 2 (JAK2). Here, we...

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Bibliographic Details
Main Authors: Chongren Tang, Ashley M. Vaughan, G.M. Anantharamaiah, John F. Oram
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter A1
cholesterol efflux
atherosclerosis
HDL
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520336609

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