Disordered clusters of Bak dimers rupture mitochondria during apoptosis

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

During apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. We have employed cysteine labelling and linkage analysis to the full length of Bak in mitochondria. This comprehensive sur...

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Bibliographic Details
Main Authors: Rachel T Uren, Martin O’Hely, Sweta Iyer, Ray Bartolo, Melissa X Shi, Jason M Brouwer, Amber E Alsop, Grant Dewson, Ruth M Kluck
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-02-01
Series:eLife
Subjects:
Bak
apoptotic pore
oligomer
Bcl-2 proteins
cell death
disordered cluster
Online Access:https://elifesciences.org/articles/19944

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