Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum
Two new acylated flavonol glycosides named kaempferol-3-O-(2-O-sinapoyl)-β-D-galactopyranosyl-(1→2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside (1) and quercetin-3-O-(6-O-benzoyl)-β-D-glucopyranosyl-(1→3)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (2), were isolated together with six known comp...
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MDPI AG
2014-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/8/11341 |
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| author | Qing-Lu Fan Yin-Di Zhu Wen-Hua Huang Yun Qi Bao-Lin Guo |
| author_facet | Qing-Lu Fan Yin-Di Zhu Wen-Hua Huang Yun Qi Bao-Lin Guo |
| author_sort | Qing-Lu Fan |
| collection | DOAJ |
| description | Two new acylated flavonol glycosides named kaempferol-3-O-(2-O-sinapoyl)-β-D-galactopyranosyl-(1→2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside (1) and quercetin-3-O-(6-O-benzoyl)-β-D-glucopyranosyl-(1→3)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (2), were isolated together with six known compounds from the seeds of L. sativum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. In vitro 1 and 2 inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC50 values of 25.36 and 25.08 µM, respectively. |
| first_indexed | 2024-12-11T16:35:59Z |
| format | Article |
| id | doaj.art-4864eb9e5c9043f1a4e104e8c4a8cb7e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T16:35:59Z |
| publishDate | 2014-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4864eb9e5c9043f1a4e104e8c4a8cb7e2022-12-22T00:58:27ZengMDPI AGMolecules1420-30492014-07-01198113411134910.3390/molecules190811341molecules190811341Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativumQing-Lu Fan0Yin-Di Zhu1Wen-Hua Huang2Yun Qi3Bao-Lin Guo4Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, ChinaTwo new acylated flavonol glycosides named kaempferol-3-O-(2-O-sinapoyl)-β-D-galactopyranosyl-(1→2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside (1) and quercetin-3-O-(6-O-benzoyl)-β-D-glucopyranosyl-(1→3)-β-D-galactopyranoside-7-O-α-L-rhamnopyranoside (2), were isolated together with six known compounds from the seeds of L. sativum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. In vitro 1 and 2 inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC50 values of 25.36 and 25.08 µM, respectively.http://www.mdpi.com/1420-3049/19/8/11341Lepidium sativumflavonol glycosideanti-inflammatory activity |
| spellingShingle | Qing-Lu Fan Yin-Di Zhu Wen-Hua Huang Yun Qi Bao-Lin Guo Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum Molecules Lepidium sativum flavonol glycoside anti-inflammatory activity |
| title | Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum |
| title_full | Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum |
| title_fullStr | Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum |
| title_full_unstemmed | Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum |
| title_short | Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum |
| title_sort | two new acylated flavonol glycosides from the seeds of lepidium sativum |
| topic | Lepidium sativum flavonol glycoside anti-inflammatory activity |
| url | http://www.mdpi.com/1420-3049/19/8/11341 |
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