State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients
Background and hypothesis: Delusions are characteristic of psychotic disorders; however, the brain correlates of delusions remain poorly known. Imaging studies on delusions typically compare images across individuals. Related confounding of inter-individual differences beyond delusions may be avoide...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222002996 |
| _version_ | 1797986448941514752 |
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| author | Jonatan M. Panula Jussi Alho Maija Lindgren Tuula Kieseppä Jaana Suvisaari Tuukka T. Raij |
| author_facet | Jonatan M. Panula Jussi Alho Maija Lindgren Tuula Kieseppä Jaana Suvisaari Tuukka T. Raij |
| author_sort | Jonatan M. Panula |
| collection | DOAJ |
| description | Background and hypothesis: Delusions are characteristic of psychotic disorders; however, the brain correlates of delusions remain poorly known. Imaging studies on delusions typically compare images across individuals. Related confounding of inter-individual differences beyond delusions may be avoided by comparing delusional and non-delusional states within individuals. Study design: We studied correlations of delusions using intra-subject correlation (intra-SC) and inter-subject correlation of functional magnetic resonance imaging (fMRI) signal time series, obtained during a movie stimulus at baseline and follow-up. We included 27 control subjects and 24 first-episode psychosis patients, who were free of delusions at follow-up, to calculate intra-SC between fMRI signals obtained during the two time points. In addition, we studied changes in functional connectivity at baseline and during the one-year follow-up using regions where delusion severity correlated with intra-SC as seeds. Results: The intra-SC correlated negatively with the baseline delusion severity in the bilateral anterior insula. In addition, we observed a subthreshold cluster in the anterior cingulate. These three regions constitute the cortical salience network (SN). Functional connectivity between the bilateral insula and the precuneus was weaker in the patients at baseline than in patients at follow-up or in control subjects at any time point. Conclusions: The results suggest that intra-SC is a powerful tool to study brain correlates of symptoms and highlight the role of the SN and internetwork dysconnectivity between the SN and the default mode network in delusions. |
| first_indexed | 2024-04-11T07:32:54Z |
| format | Article |
| id | doaj.art-4864fba07fa343e78f0605b4b09e4af2 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-11T07:32:54Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-4864fba07fa343e78f0605b4b09e4af22022-12-22T04:36:49ZengElsevierNeuroImage: Clinical2213-15822022-01-0136103234State-like changes in the salience network correlate with delusion severity in first-episode psychosis patientsJonatan M. Panula0Jussi Alho1Maija Lindgren2Tuula Kieseppä3Jaana Suvisaari4Tuukka T. Raij5Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Neuroscience and Biomedical Engineering and Advanced Magnetic Imaging Center, Aalto University School of Science, Espoo, Finland; Corresponding author at: University of Helsinki, Department of Psychiatry, Välskärinkatu 12 00014, Helsinki, Finland.Department of Neuroscience and Biomedical Engineering and Advanced Magnetic Imaging Center, Aalto University School of Science, Espoo, FinlandMental Health, Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FinlandDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FinlandMental Health, Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, FinlandDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Neuroscience and Biomedical Engineering and Advanced Magnetic Imaging Center, Aalto University School of Science, Espoo, FinlandBackground and hypothesis: Delusions are characteristic of psychotic disorders; however, the brain correlates of delusions remain poorly known. Imaging studies on delusions typically compare images across individuals. Related confounding of inter-individual differences beyond delusions may be avoided by comparing delusional and non-delusional states within individuals. Study design: We studied correlations of delusions using intra-subject correlation (intra-SC) and inter-subject correlation of functional magnetic resonance imaging (fMRI) signal time series, obtained during a movie stimulus at baseline and follow-up. We included 27 control subjects and 24 first-episode psychosis patients, who were free of delusions at follow-up, to calculate intra-SC between fMRI signals obtained during the two time points. In addition, we studied changes in functional connectivity at baseline and during the one-year follow-up using regions where delusion severity correlated with intra-SC as seeds. Results: The intra-SC correlated negatively with the baseline delusion severity in the bilateral anterior insula. In addition, we observed a subthreshold cluster in the anterior cingulate. These three regions constitute the cortical salience network (SN). Functional connectivity between the bilateral insula and the precuneus was weaker in the patients at baseline than in patients at follow-up or in control subjects at any time point. Conclusions: The results suggest that intra-SC is a powerful tool to study brain correlates of symptoms and highlight the role of the SN and internetwork dysconnectivity between the SN and the default mode network in delusions.http://www.sciencedirect.com/science/article/pii/S2213158222002996DelusionsFirst-episode psychosisfMRIIntra-subject correlation |
| spellingShingle | Jonatan M. Panula Jussi Alho Maija Lindgren Tuula Kieseppä Jaana Suvisaari Tuukka T. Raij State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients NeuroImage: Clinical Delusions First-episode psychosis fMRI Intra-subject correlation |
| title | State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients |
| title_full | State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients |
| title_fullStr | State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients |
| title_full_unstemmed | State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients |
| title_short | State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients |
| title_sort | state like changes in the salience network correlate with delusion severity in first episode psychosis patients |
| topic | Delusions First-episode psychosis fMRI Intra-subject correlation |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222002996 |
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