Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children
BackgroundOrthostatic intolerance (OI) is usually mediated by the autonomic nerve and most often happens in the upright position. However, it can also occur in other positions and can be relieved by lying down while likely to have another attack after relief. In the current study, we aim to evaluate...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1220990/full |
| _version_ | 1827856694847209472 |
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| author | Lujie Chang Lu Peng Jianglin Liu Minmin Wang Meng Li Qingyu Kong Haizhao Zhao Cuifen Zhao |
| author_facet | Lujie Chang Lu Peng Jianglin Liu Minmin Wang Meng Li Qingyu Kong Haizhao Zhao Cuifen Zhao |
| author_sort | Lujie Chang |
| collection | DOAJ |
| description | BackgroundOrthostatic intolerance (OI) is usually mediated by the autonomic nerve and most often happens in the upright position. However, it can also occur in other positions and can be relieved by lying down while likely to have another attack after relief. In the current study, we aim to evaluate the predictive effect of catecholamines and electrolytes on the recurrence of OI in children.Materials and methodsChildren who were diagnosed with vasovagal syncope (VVS), postural tachycardia syndrome (POTS), and VVS combined with POTS were enrolled in this retrospective study and were followed up after 1-year physical treatment. Catecholamines in urine collected within 24 h, renin, angiotensin II, aldosterone in plasma, and electrolytes in both blood and urine collected in the morning were tested. A multivariate analysis and a receiver operating characteristic curve were used to validate the prediction effect.ResultsIn the VVS cohort, the 24 h urine adrenaline (AD) and norepinephrine (NE) levels of the non-recurrence group were lower than the 24 h urine AD and NE levels of the recurrence group, with a significant difference of P < 0.05. A different content can also be witnessed in the POTS cohort that the urine of the non-recurrence group contained lower sodium and chlorine. As for the VVS + POTS cohort, the non-recurrence group has lower AD and NE levels and higher potassium and phosphorus levels in urine, the difference of which proved prominent as well.ConclusionThe study provides further evidence that AD, NE, and electrolytes in urine are promising factors that are closely related to the recurrence of OI in children. The integrated evaluation system merging AD and NE may have better predictive ability. |
| first_indexed | 2024-03-12T12:29:28Z |
| format | Article |
| id | doaj.art-48654d5ba4cb489b8cec79bc07205b59 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-12T12:29:28Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-48654d5ba4cb489b8cec79bc07205b592023-08-29T16:08:44ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-08-011110.3389/fped.2023.12209901220990Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in childrenLujie ChangLu PengJianglin LiuMinmin WangMeng LiQingyu KongHaizhao ZhaoCuifen ZhaoBackgroundOrthostatic intolerance (OI) is usually mediated by the autonomic nerve and most often happens in the upright position. However, it can also occur in other positions and can be relieved by lying down while likely to have another attack after relief. In the current study, we aim to evaluate the predictive effect of catecholamines and electrolytes on the recurrence of OI in children.Materials and methodsChildren who were diagnosed with vasovagal syncope (VVS), postural tachycardia syndrome (POTS), and VVS combined with POTS were enrolled in this retrospective study and were followed up after 1-year physical treatment. Catecholamines in urine collected within 24 h, renin, angiotensin II, aldosterone in plasma, and electrolytes in both blood and urine collected in the morning were tested. A multivariate analysis and a receiver operating characteristic curve were used to validate the prediction effect.ResultsIn the VVS cohort, the 24 h urine adrenaline (AD) and norepinephrine (NE) levels of the non-recurrence group were lower than the 24 h urine AD and NE levels of the recurrence group, with a significant difference of P < 0.05. A different content can also be witnessed in the POTS cohort that the urine of the non-recurrence group contained lower sodium and chlorine. As for the VVS + POTS cohort, the non-recurrence group has lower AD and NE levels and higher potassium and phosphorus levels in urine, the difference of which proved prominent as well.ConclusionThe study provides further evidence that AD, NE, and electrolytes in urine are promising factors that are closely related to the recurrence of OI in children. The integrated evaluation system merging AD and NE may have better predictive ability.https://www.frontiersin.org/articles/10.3389/fped.2023.1220990/fullchildrencatecholamineselectrolytesurine testorthostatic intoleranceprediction of recurrence |
| spellingShingle | Lujie Chang Lu Peng Jianglin Liu Minmin Wang Meng Li Qingyu Kong Haizhao Zhao Cuifen Zhao Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children Frontiers in Pediatrics children catecholamines electrolytes urine test orthostatic intolerance prediction of recurrence |
| title | Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children |
| title_full | Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children |
| title_fullStr | Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children |
| title_full_unstemmed | Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children |
| title_short | Predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children |
| title_sort | predictive analysis of catecholamines and electrolytes for recurrence of orthostatic intolerance in children |
| topic | children catecholamines electrolytes urine test orthostatic intolerance prediction of recurrence |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1220990/full |
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