PrEP risk perception and adherence among men who have sex with men: a prospective cohort study based on growth mixture model
Abstract Background It can be considered that pre-exposure prophylaxis (PrEP) risk perception is the negative experiences or concerns about taking PrEP. The aim of this study is to explore the longitudinal trajectory of PrEP risk perception among men who have sex with men (MSM) and its impact on adh...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07966-3 |
| _version_ | 1797973692280471552 |
|---|---|
| author | Bing Lin Jiaxiu Liu Xiaoni Zhong |
| author_facet | Bing Lin Jiaxiu Liu Xiaoni Zhong |
| author_sort | Bing Lin |
| collection | DOAJ |
| description | Abstract Background It can be considered that pre-exposure prophylaxis (PrEP) risk perception is the negative experiences or concerns about taking PrEP. The aim of this study is to explore the longitudinal trajectory of PrEP risk perception among men who have sex with men (MSM) and its impact on adherence. Methods Data related to PrEP risk perception and adherence were derived from a prospective cohort study in Western China from 2013 to 2015. Subjects were categorized into the time-driven, event-driven and blank control groups. Tenofovir disoproxil fumarate (TDF) was administered to subjects in the time-driven and event-driven groups, and all subjects were followed up every 12 weeks. The PrEP risk perception scale was constructed, and the growth mixture model (GMM) was used to classify longitudinal PrEP risk perception. The effect of different levels of PrEP risk perception on drug adherence was explored using generalized estimating equations (GEE) with relative risk (RR) and 95% confidence interval (CI). Results The PrEP risk perception scale consists of 4 dimensions and 16 items with Cronbach's alpha = 0.828 and a good model fit. According to the GMM analysis, the subjects' PrEP risk perceptions were separated into two groups: a "high-risk perception group" (n = 133) and a "low-risk perception group" (n = 493), where the proportion of high levels of drug adherence were 57.89% and 68.35%, respectively (p = 0.024). High levels of PrEP risk perception in the MSM population hinder drug adherence (RR = 0.71, 95% CI 0.50 to 0.99, p = 0.046). The results of this study were validated in the subsequent PrEP projects conducted in 2019 to 2021. Conclusion This study demonstrates that high levels of PrEP risk perception in the MSM population are an obstacle to drug adherence, emphasizing the necessity of focusing on PrEP risk perception in this population and the value of its application in the current context. |
| first_indexed | 2024-04-11T04:08:22Z |
| format | Article |
| id | doaj.art-4866c965f7dc48ac9a96aac09dd0a831 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-11T04:08:22Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-4866c965f7dc48ac9a96aac09dd0a8312023-01-01T12:13:54ZengBMCBMC Infectious Diseases1471-23342022-12-0122111410.1186/s12879-022-07966-3PrEP risk perception and adherence among men who have sex with men: a prospective cohort study based on growth mixture modelBing Lin0Jiaxiu Liu1Xiaoni Zhong2School of Public Health, Chongqing Medical UniversitySchool of Medical Informatics, Chongqing Medical UniversitySchool of Public Health, Chongqing Medical UniversityAbstract Background It can be considered that pre-exposure prophylaxis (PrEP) risk perception is the negative experiences or concerns about taking PrEP. The aim of this study is to explore the longitudinal trajectory of PrEP risk perception among men who have sex with men (MSM) and its impact on adherence. Methods Data related to PrEP risk perception and adherence were derived from a prospective cohort study in Western China from 2013 to 2015. Subjects were categorized into the time-driven, event-driven and blank control groups. Tenofovir disoproxil fumarate (TDF) was administered to subjects in the time-driven and event-driven groups, and all subjects were followed up every 12 weeks. The PrEP risk perception scale was constructed, and the growth mixture model (GMM) was used to classify longitudinal PrEP risk perception. The effect of different levels of PrEP risk perception on drug adherence was explored using generalized estimating equations (GEE) with relative risk (RR) and 95% confidence interval (CI). Results The PrEP risk perception scale consists of 4 dimensions and 16 items with Cronbach's alpha = 0.828 and a good model fit. According to the GMM analysis, the subjects' PrEP risk perceptions were separated into two groups: a "high-risk perception group" (n = 133) and a "low-risk perception group" (n = 493), where the proportion of high levels of drug adherence were 57.89% and 68.35%, respectively (p = 0.024). High levels of PrEP risk perception in the MSM population hinder drug adherence (RR = 0.71, 95% CI 0.50 to 0.99, p = 0.046). The results of this study were validated in the subsequent PrEP projects conducted in 2019 to 2021. Conclusion This study demonstrates that high levels of PrEP risk perception in the MSM population are an obstacle to drug adherence, emphasizing the necessity of focusing on PrEP risk perception in this population and the value of its application in the current context.https://doi.org/10.1186/s12879-022-07966-3Pre-exposure prophylaxisRisk perceptionMen who have sex with menAdherenceGrowth mixture model |
| spellingShingle | Bing Lin Jiaxiu Liu Xiaoni Zhong PrEP risk perception and adherence among men who have sex with men: a prospective cohort study based on growth mixture model BMC Infectious Diseases Pre-exposure prophylaxis Risk perception Men who have sex with men Adherence Growth mixture model |
| title | PrEP risk perception and adherence among men who have sex with men: a prospective cohort study based on growth mixture model |
| title_full | PrEP risk perception and adherence among men who have sex with men: a prospective cohort study based on growth mixture model |
| title_fullStr | PrEP risk perception and adherence among men who have sex with men: a prospective cohort study based on growth mixture model |
| title_full_unstemmed | PrEP risk perception and adherence among men who have sex with men: a prospective cohort study based on growth mixture model |
| title_short | PrEP risk perception and adherence among men who have sex with men: a prospective cohort study based on growth mixture model |
| title_sort | prep risk perception and adherence among men who have sex with men a prospective cohort study based on growth mixture model |
| topic | Pre-exposure prophylaxis Risk perception Men who have sex with men Adherence Growth mixture model |
| url | https://doi.org/10.1186/s12879-022-07966-3 |
| work_keys_str_mv | AT binglin prepriskperceptionandadherenceamongmenwhohavesexwithmenaprospectivecohortstudybasedongrowthmixturemodel AT jiaxiuliu prepriskperceptionandadherenceamongmenwhohavesexwithmenaprospectivecohortstudybasedongrowthmixturemodel AT xiaonizhong prepriskperceptionandadherenceamongmenwhohavesexwithmenaprospectivecohortstudybasedongrowthmixturemodel |