Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI study
Positron emission tomography (PET) can be used for in vivo measurement of specific neuroreceptors and transporters using radioligands, while voxel-based morphometric analysis of magnetic resonance images allows automated estimation of local grey matter densities. However, it is not known how regiona...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921002457 |
| _version_ | 1819103155093241856 |
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| author | Sandra Manninen Tomi Karjalainen Lauri J. Tuominen Jarmo Hietala Valtteri Kaasinen Juho Joutsa Juha Rinne Lauri Nummenmaa |
| author_facet | Sandra Manninen Tomi Karjalainen Lauri J. Tuominen Jarmo Hietala Valtteri Kaasinen Juho Joutsa Juha Rinne Lauri Nummenmaa |
| author_sort | Sandra Manninen |
| collection | DOAJ |
| description | Positron emission tomography (PET) can be used for in vivo measurement of specific neuroreceptors and transporters using radioligands, while voxel-based morphometric analysis of magnetic resonance images allows automated estimation of local grey matter densities. However, it is not known how regional neuroreceptor or transporter densities are reflected in grey matter densities. Here, we analyzed brain scans retrospectively from 328 subjects and compared grey matter density estimates with neuroreceptor and transporter availabilities. µ-opioid receptors (MORs) were measured with [11C]carfentanil (162 scans), dopamine D2 receptors with [11C]raclopride (92 scans) and serotonin transporters (SERT) with [11C]MADAM (74 scans). The PET data were modelled with simplified reference tissue model. Voxel-wise correlations between binding potential and grey matter density images were computed. Regional binding of all the used radiotracers was associated with grey matter density in region and ligand-specific manner independently of subjects’ age or sex. These data show that grey matter density and MOR and D2R neuroreceptor / SERT availability are correlated, with effect sizes (r2) ranging from 0.04 to 0.69. This suggests that future studies comparing PET outcome measure different groups (such as patients and controls) should also analyze interactive effects of grey matter density and PET outcome measures. |
| first_indexed | 2024-12-22T01:45:57Z |
| format | Article |
| id | doaj.art-4868b63b1af943e8aaf8e5c004a239c3 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-22T01:45:57Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-4868b63b1af943e8aaf8e5c004a239c32022-12-21T18:43:05ZengElsevierNeuroImage1095-95722021-07-01235117968Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI studySandra Manninen0Tomi Karjalainen1Lauri J. Tuominen2Jarmo Hietala3Valtteri Kaasinen4Juho Joutsa5Juha Rinne6Lauri Nummenmaa7Turku Pet Centre and Turku University Hospital, Turku, Finland; Corresponding author.Turku Pet Centre and Turku University Hospital, Turku, FinlandTurku Pet Centre and Turku University Hospital, Turku, Finland; University of Ottawa, Institute of Mental Health Research, Ottawa, Ontario, CanadaDepartment of Psychiatry, Turku University Hospital, Turku, FinlandClinical Neurosciences, University of Turku, Turku, FinlandClinical Neurosciences, University of Turku, Turku, FinlandTurku Pet Centre and Turku University Hospital, Turku, FinlandTurku Pet Centre and Turku University Hospital, Turku, Finland; Department of Psychology, University of Turku, FinlandPositron emission tomography (PET) can be used for in vivo measurement of specific neuroreceptors and transporters using radioligands, while voxel-based morphometric analysis of magnetic resonance images allows automated estimation of local grey matter densities. However, it is not known how regional neuroreceptor or transporter densities are reflected in grey matter densities. Here, we analyzed brain scans retrospectively from 328 subjects and compared grey matter density estimates with neuroreceptor and transporter availabilities. µ-opioid receptors (MORs) were measured with [11C]carfentanil (162 scans), dopamine D2 receptors with [11C]raclopride (92 scans) and serotonin transporters (SERT) with [11C]MADAM (74 scans). The PET data were modelled with simplified reference tissue model. Voxel-wise correlations between binding potential and grey matter density images were computed. Regional binding of all the used radiotracers was associated with grey matter density in region and ligand-specific manner independently of subjects’ age or sex. These data show that grey matter density and MOR and D2R neuroreceptor / SERT availability are correlated, with effect sizes (r2) ranging from 0.04 to 0.69. This suggests that future studies comparing PET outcome measure different groups (such as patients and controls) should also analyze interactive effects of grey matter density and PET outcome measures.http://www.sciencedirect.com/science/article/pii/S1053811921002457MRINeuroreceptorsNeurotransportersPETVoxel-based morphometry |
| spellingShingle | Sandra Manninen Tomi Karjalainen Lauri J. Tuominen Jarmo Hietala Valtteri Kaasinen Juho Joutsa Juha Rinne Lauri Nummenmaa Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI study NeuroImage MRI Neuroreceptors Neurotransporters PET Voxel-based morphometry |
| title | Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI study |
| title_full | Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI study |
| title_fullStr | Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI study |
| title_full_unstemmed | Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI study |
| title_short | Cerebral grey matter density is associated with neuroreceptor and neurotransporter availability: A combined PET and MRI study |
| title_sort | cerebral grey matter density is associated with neuroreceptor and neurotransporter availability a combined pet and mri study |
| topic | MRI Neuroreceptors Neurotransporters PET Voxel-based morphometry |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921002457 |
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