Contingency and selection in mitochondrial genome dynamics
High frequencies of mutant mitochondrial DNA (mtDNA) in human cells lead to cellular defects that are associated with aging and disease. Yet much remains to be understood about the dynamics of the generation of mutant mtDNAs and their relative replicative fitness that informs their fate within cells...
Main Authors: | Christopher J Nunn, Sidhartha Goyal |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-04-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/76557 |
Similar Items
-
Impact of Salmonella genome rearrangement on gene expression
by: Emma V. Waters, et al.
Published: (2022-12-01) -
Nanopore sequencing data and structural variants identified in Prunus avium seedlings derived through mutagenesis
by: Per McCord, et al.
Published: (2022-08-01) -
Benchmarking long-read genome sequence alignment tools for human genomics applications
by: Jonathan LoTempio, et al.
Published: (2023-12-01) -
Benchmarking Long-Read Assemblers for Genomic Analyses of Bacterial Pathogens Using Oxford Nanopore Sequencing
by: Zhao Chen, et al.
Published: (2020-12-01) -
Comparison of De Novo Assembly Strategies for Bacterial Genomes
by: Pengfei Zhang, et al.
Published: (2021-07-01)