Catenane organocatalyst breaks the linear scaling limitation through conformational selection
Conformational dynamics are integral to enzyme catalysis, yet they are barely explored when designing synthetic catalysts. Now, a catenane-based organocatalyst, which dynamically switches between two conformations, speeds up the catalysis of carbodiimide hydration through spontaneous conformational...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Communications Chemistry |
| Online Access: | https://doi.org/10.1038/s42004-023-01088-w |
| _version_ | 1827382331097219072 |
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| author | Chenyu Wang |
| author_facet | Chenyu Wang |
| author_sort | Chenyu Wang |
| collection | DOAJ |
| description | Conformational dynamics are integral to enzyme catalysis, yet they are barely explored when designing synthetic catalysts. Now, a catenane-based organocatalyst, which dynamically switches between two conformations, speeds up the catalysis of carbodiimide hydration through spontaneous conformational adaptation for different reaction steps. |
| first_indexed | 2024-03-08T14:18:03Z |
| format | Article |
| id | doaj.art-486c177624b94dcd99090412555e3338 |
| institution | Directory Open Access Journal |
| issn | 2399-3669 |
| language | English |
| last_indexed | 2024-03-08T14:18:03Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Chemistry |
| spelling | doaj.art-486c177624b94dcd99090412555e33382024-01-14T12:14:58ZengNature PortfolioCommunications Chemistry2399-36692024-01-01711210.1038/s42004-023-01088-wCatenane organocatalyst breaks the linear scaling limitation through conformational selectionChenyu Wang0Scientific ReportsConformational dynamics are integral to enzyme catalysis, yet they are barely explored when designing synthetic catalysts. Now, a catenane-based organocatalyst, which dynamically switches between two conformations, speeds up the catalysis of carbodiimide hydration through spontaneous conformational adaptation for different reaction steps.https://doi.org/10.1038/s42004-023-01088-w |
| spellingShingle | Chenyu Wang Catenane organocatalyst breaks the linear scaling limitation through conformational selection Communications Chemistry |
| title | Catenane organocatalyst breaks the linear scaling limitation through conformational selection |
| title_full | Catenane organocatalyst breaks the linear scaling limitation through conformational selection |
| title_fullStr | Catenane organocatalyst breaks the linear scaling limitation through conformational selection |
| title_full_unstemmed | Catenane organocatalyst breaks the linear scaling limitation through conformational selection |
| title_short | Catenane organocatalyst breaks the linear scaling limitation through conformational selection |
| title_sort | catenane organocatalyst breaks the linear scaling limitation through conformational selection |
| url | https://doi.org/10.1038/s42004-023-01088-w |
| work_keys_str_mv | AT chenyuwang catenaneorganocatalystbreaksthelinearscalinglimitationthroughconformationalselection |