Polynucleotide Phosphorylase Mediates a New Mechanism of Persister Formation in Escherichia coli

Polynucleotide Phosphorylase Mediates a New Mechanism of Persister Formation in Escherichia coli

ABSTRACT Despite the identification of many genes and pathways involved in the persistence phenomenon in bacteria, the mechanisms of persistence are not well understood. Here, using Escherichia coli, we identified polynucleotide phosphorylase (PNPase) as a key regulator of persister formation. We co...

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Bibliographic Details
Main Authors: Nan Wu, Yumeng Zhang, Shanshan Zhang, Youhua Yuan, Shuang Liu, Tao Xu, Peng Cui, Wenhong Zhang, Ying Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
PNPase
Escherichia coli
persister mechanisms
cyclic AMP receptor protein
persister cells
knockout
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01546-22

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