Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing
Silk fibroin (SF), an organic material obtained from the cocoons of a silkworm <i>Bombyx mori</i>, is used in several applications and has a proven track record in biomedicine owing to its superior compatibility with the human body, superb mechanical characteristics, and its controllable...
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/14421 |
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| author | Shahid Ud Din Wani Mohammed Iqbal Zargar Mubashir Hussain Masoodi Sultan Alshehri Prawez Alam Mohammed M. Ghoneim Areej Alshlowi H. G. Shivakumar Mohammad Ali Faiyaz Shakeel |
| author_facet | Shahid Ud Din Wani Mohammed Iqbal Zargar Mubashir Hussain Masoodi Sultan Alshehri Prawez Alam Mohammed M. Ghoneim Areej Alshlowi H. G. Shivakumar Mohammad Ali Faiyaz Shakeel |
| author_sort | Shahid Ud Din Wani |
| collection | DOAJ |
| description | Silk fibroin (SF), an organic material obtained from the cocoons of a silkworm <i>Bombyx mori</i>, is used in several applications and has a proven track record in biomedicine owing to its superior compatibility with the human body, superb mechanical characteristics, and its controllable propensity to decay. Due to its robust biocompatibility, less immunogenic, non-toxic, non-carcinogenic, and biodegradable properties, it has been widely used in biological and biomedical fields, including wound healing. The key strategies for building diverse SF-based drug delivery systems are discussed in this review, as well as the most recent ways for developing functionalized SF for controlled or redirected medicines, gene therapy, and wound healing. Understanding the features of SF and the various ways to manipulate its physicochemical and mechanical properties enables the development of more effective drug delivery devices. Drugs are encapsulated in SF-based drug delivery systems to extend their shelf life and control their release, allowing them to travel further across the bloodstream and thus extend their range of operation. Furthermore, due to their tunable properties, SF-based drug delivery systems open up new possibilities for drug delivery, gene therapy, and wound healing. |
| first_indexed | 2024-03-09T18:15:35Z |
| format | Article |
| id | doaj.art-486cdb3a1e2741eb8c23195d1c821b2c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:15:35Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-486cdb3a1e2741eb8c23195d1c821b2c2023-11-24T08:44:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221442110.3390/ijms232214421Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound HealingShahid Ud Din Wani0Mohammed Iqbal Zargar1Mubashir Hussain Masoodi2Sultan Alshehri3Prawez Alam4Mohammed M. Ghoneim5Areej Alshlowi6H. G. Shivakumar7Mohammad Ali8Faiyaz Shakeel9Department of Pharmaceutical Sciences, School of Applied Science and Technology, University of Kashmir, Jammu and Kashmir, Srinagar 190006, IndiaDepartment of Pharmaceutical Sciences, School of Applied Science and Technology, University of Kashmir, Jammu and Kashmir, Srinagar 190006, IndiaDepartment of Pharmaceutical Sciences, School of Applied Science and Technology, University of Kashmir, Jammu and Kashmir, Srinagar 190006, IndiaDepartment of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, JSS Academy of Technical Education, Noida 201301, IndiaDepartment of Pharmacy Practice, East Point College of Pharmacy, Bangalore 560049, IndiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaSilk fibroin (SF), an organic material obtained from the cocoons of a silkworm <i>Bombyx mori</i>, is used in several applications and has a proven track record in biomedicine owing to its superior compatibility with the human body, superb mechanical characteristics, and its controllable propensity to decay. Due to its robust biocompatibility, less immunogenic, non-toxic, non-carcinogenic, and biodegradable properties, it has been widely used in biological and biomedical fields, including wound healing. The key strategies for building diverse SF-based drug delivery systems are discussed in this review, as well as the most recent ways for developing functionalized SF for controlled or redirected medicines, gene therapy, and wound healing. Understanding the features of SF and the various ways to manipulate its physicochemical and mechanical properties enables the development of more effective drug delivery devices. Drugs are encapsulated in SF-based drug delivery systems to extend their shelf life and control their release, allowing them to travel further across the bloodstream and thus extend their range of operation. Furthermore, due to their tunable properties, SF-based drug delivery systems open up new possibilities for drug delivery, gene therapy, and wound healing.https://www.mdpi.com/1422-0067/23/22/14421silk fibroinbiopolymersbiomaterialsdrug delivery applicationswound healinggene therapy |
| spellingShingle | Shahid Ud Din Wani Mohammed Iqbal Zargar Mubashir Hussain Masoodi Sultan Alshehri Prawez Alam Mohammed M. Ghoneim Areej Alshlowi H. G. Shivakumar Mohammad Ali Faiyaz Shakeel Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing International Journal of Molecular Sciences silk fibroin biopolymers biomaterials drug delivery applications wound healing gene therapy |
| title | Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing |
| title_full | Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing |
| title_fullStr | Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing |
| title_full_unstemmed | Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing |
| title_short | Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing |
| title_sort | silk fibroin as an efficient biomaterial for drug delivery gene therapy and wound healing |
| topic | silk fibroin biopolymers biomaterials drug delivery applications wound healing gene therapy |
| url | https://www.mdpi.com/1422-0067/23/22/14421 |
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