Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation

Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation

The generation of diverse neuronal subtypes involves specification of neural progenitors and, subsequently, postmitotic neuronal differentiation, a relatively poorly understood process. Here, we describe a mechanism whereby the neurotrophic factor NGF and the transcription factor Runx1 coordinate po...

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Bibliographic Details
Main Authors: Siyi Huang, Kevin J O'Donovan, Eric E Turner, Jian Zhong, David D Ginty
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
NGF
Runx1/CBFB
nociceptor differentiation
convergence of extrinsic and intrinsic factors
Online Access:https://elifesciences.org/articles/10874

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