Phospholipase C signaling activated by parathyroid hormone mediates the rapid osteoclastogenesis in the fracture healing of orchiectomized mice

Phospholipase C signaling activated by parathyroid hormone mediates the rapid osteoclastogenesis in the fracture healing of orchiectomized mice

Abstract Background The age-related osteoporosis is an increasing risk severely threatening the live quality of aged people. Human parathyroid hormone (hPTH) is applied to the therapy of osteoporosis successfully, however, the mechanism, especially the signaling pathway activated in the healing frac...

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Bibliographic Details
Main Authors: Wei Li, Liang Yuan, Guojun Tong, Youhua He, Yue Meng, Song Hao, Jianting Chen, Jun Guo, Richard Bringhurst, Dehong Yang
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Musculoskeletal Disorders
Subjects:
Parathyroid hormone
Fracture healing
Phopholipase C
Osteoporosis
Osteoclastogenesis
Online Access:http://link.springer.com/article/10.1186/s12891-018-2231-3

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