MicroRNA-155 governs SHIP-1 expression and localization in NK cells and regulates subsequent infiltration into murine AT3 mammary carcinoma.

MicroRNA-155 governs SHIP-1 expression and localization in NK cells and regulates subsequent infiltration into murine AT3 mammary carcinoma.

NK cell migration and activation are crucial elements of tumor immune surveillance. In mammary carcinomas, the number and function of NK cells is diminished, despite being positively associated with clinical outcome. MicroRNA-155 (miR-155) has been shown to be an important regulator of NK cell activ...

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Bibliographic Details
Main Authors: Wendy M Kandell, Sarah S Donatelli, Thu Le Trinh, Alexandra R Calescibetta, Tina So, Nhan Tu, Danielle L Gilvary, Xianghong Chen, Pingyan Cheng, William A Adams, Yin-Kai Chen, Jinhong Liu, Julie Y Djeu, Sheng Wei, Erika A Eksioglu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0225820

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