Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib
Several cases of STRN-ALK fusion have been reported, and some anaplastic lymphoma kinase (ALK) inhibitors have been shown to be effective for treatment. Nevertheless, no cases of COVID-19 leading to heart failure and respiratory failure have been reported in people older than 70 years treated with A...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1235679/full |
| _version_ | 1827809138463211520 |
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| author | Guo-qiang Song Yi-zhong Li Weiliang Kong Guo-qiang Hu |
| author_facet | Guo-qiang Song Yi-zhong Li Weiliang Kong Guo-qiang Hu |
| author_sort | Guo-qiang Song |
| collection | DOAJ |
| description | Several cases of STRN-ALK fusion have been reported, and some anaplastic lymphoma kinase (ALK) inhibitors have been shown to be effective for treatment. Nevertheless, no cases of COVID-19 leading to heart failure and respiratory failure have been reported in people older than 70 years treated with ALK inhibitors. The present case report describes a 70-year-old patient with usual chronic obstructive pulmonary disease, diabetes, depression, and carotid plaque disease. Next-generation sequencing of tissue obtained by puncture biopsy revealed a STRN-ALK mutation accompanied by a TP53 mutation. The patient was treated with ensartinib and developed COVID-19 leading to heart failure and respiratory failure; nevertheless, he had a good clinical outcome and exhibited high treatment tolerability. |
| first_indexed | 2024-03-11T22:38:40Z |
| format | Article |
| id | doaj.art-48708f98fb6541ca8e05fff86076a3a4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T22:38:40Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-48708f98fb6541ca8e05fff86076a3a42023-09-22T10:24:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-09-011310.3389/fonc.2023.12356791235679Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinibGuo-qiang Song0Yi-zhong Li1Weiliang Kong2Guo-qiang Hu3Department of Respiratory, Changxing County Hospital of Traditional Chinese Medicine, Huzhou, ChinaDepartment of Respiratory, Changxing County Jiapu Town Health Center, Huzhou, ChinaDepartment of Pathology, Changxing County Hospital of Traditional Chinese Medicine, Huzhou, ChinaDepartment of Respiratory, Changxing County Hospital of Traditional Chinese Medicine, Huzhou, ChinaSeveral cases of STRN-ALK fusion have been reported, and some anaplastic lymphoma kinase (ALK) inhibitors have been shown to be effective for treatment. Nevertheless, no cases of COVID-19 leading to heart failure and respiratory failure have been reported in people older than 70 years treated with ALK inhibitors. The present case report describes a 70-year-old patient with usual chronic obstructive pulmonary disease, diabetes, depression, and carotid plaque disease. Next-generation sequencing of tissue obtained by puncture biopsy revealed a STRN-ALK mutation accompanied by a TP53 mutation. The patient was treated with ensartinib and developed COVID-19 leading to heart failure and respiratory failure; nevertheless, he had a good clinical outcome and exhibited high treatment tolerability.https://www.frontiersin.org/articles/10.3389/fonc.2023.1235679/fullSTRN-ALKNSCLCensartinibcase reportTKIs |
| spellingShingle | Guo-qiang Song Yi-zhong Li Weiliang Kong Guo-qiang Hu Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib Frontiers in Oncology STRN-ALK NSCLC ensartinib case report TKIs |
| title | Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib |
| title_full | Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib |
| title_fullStr | Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib |
| title_full_unstemmed | Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib |
| title_short | Case Report: A rare case of non-small cell lung cancer with STRN-ALK fusion in a patient in very poor condition treated with first-line ensartinib |
| title_sort | case report a rare case of non small cell lung cancer with strn alk fusion in a patient in very poor condition treated with first line ensartinib |
| topic | STRN-ALK NSCLC ensartinib case report TKIs |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1235679/full |
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