Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models

Estradiol enhanced neuronal plasticity and ameliorated astrogliosis in human iPSC-derived neural models

Introduction: 17β-Estradiol (E2) is a sex hormone that has been previously demonstrated to have neurotherapeutic effects on animal models of Alzheimer's disease (AD). However, clinical trials on E2 replacement therapy for preventing AD onset yielded inconsistent results. Therefore, it is impera...

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Bibliographic Details
Main Authors:	Sopak Supakul, Chisato Oyama, Yuki Hatakeyama, Sumihiro Maeda, Hideyuki Okano
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Series:	Regenerative Therapy
Subjects:	17β-estradiol Alzheimer's disease Induced pluripotent stem cells (iPSCs) Neurons Astrocytes
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352320423001517

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