Optical coherence tomography angiography characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy
AIM: To describe the optical coherence tomography angiography (OCTA) characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy (PNV). METHODS: Thirty-five patients with exudative treatment-naïve PNV and 13 with non-exudative treatment-naïve PNV between March 2020 an...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2023-12-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2023/12/20231215.pdf |
| _version_ | 1827672139090624512 |
|---|---|
| author | Chun Yang Zu-Hua Sun Ting-Ye Zhou Wei-Wei Zheng Xiao-Ling Liu Bing Lin |
| author_facet | Chun Yang Zu-Hua Sun Ting-Ye Zhou Wei-Wei Zheng Xiao-Ling Liu Bing Lin |
| author_sort | Chun Yang |
| collection | DOAJ |
| description | AIM: To describe the optical coherence tomography angiography (OCTA) characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy (PNV). METHODS: Thirty-five patients with exudative treatment-naïve PNV and 13 with non-exudative treatment-naïve PNV between March 2020 and December 2021 were included. All patients underwent ophthalmologic examination, including fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain OCT, and OCTA. The clinical data of the patients were retrospectively analyzed. RESULTS: The study included 51 eyes from 46 patients, of whom 33 (71.7%) were male. The central macular thickness (CMT) in the exudative PNV group was significantly higher than that in the non-exudative PNV group (383.97±132.16 µm vs 213.13±51.63 µm; P<0.001). The maximum height of flat irregular pigment epithelial detachments (FIPED) was 45.40±11.86 μm in the non-exudative PNV group, significantly lower than the 71.58±20.91 μm (P<0.001) in the exudative PNV group. The area of PNV of the non-exudative PNV group was, significantly larger than that of the exudative PNV group (1.06±0.84 mm2 vs 0.63±0.80 mm2, P=0.016). There was a significant difference in PNV morphology between the two groups (P<0.001). Multivariate logistic regression analysis found that the maximum height of FIPED (OR=1.156, 95%CI: 1.019-1.312; P=0.024) and microvascular branches (OR=69.412, 95%CI: 3.538-1361.844; P=0.005) were independent predictors of PNV activity. CONCLUSION: The OCTA imaging finds that there are significant differences in CMT, maximum height of FIPED, PNV area, and morphology of exudative PNV and non-exudative PNV groups. OCTA can accurately identify the clinical and imaging features of exudative and non-exudative treatment-naïve PNV, and distinguish PNV activity. |
| first_indexed | 2024-03-10T03:57:21Z |
| format | Article |
| id | doaj.art-4871750f46d84c66850ce02c589e9359 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-03-10T03:57:21Z |
| publishDate | 2023-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-4871750f46d84c66850ce02c589e93592023-11-23T08:41:41ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982023-12-0116122027203310.18240/ijo.2023.12.1520231215Optical coherence tomography angiography characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathyChun Yang0Zu-Hua Sun1Ting-Ye Zhou2Wei-Wei Zheng3Xiao-Ling Liu4Bing Lin5Bing Lin. Eye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. linbing@wmu.edu.cnEye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, ChinaEye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, ChinaEye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, ChinaEye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, ChinaEye Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, ChinaAIM: To describe the optical coherence tomography angiography (OCTA) characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy (PNV). METHODS: Thirty-five patients with exudative treatment-naïve PNV and 13 with non-exudative treatment-naïve PNV between March 2020 and December 2021 were included. All patients underwent ophthalmologic examination, including fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain OCT, and OCTA. The clinical data of the patients were retrospectively analyzed. RESULTS: The study included 51 eyes from 46 patients, of whom 33 (71.7%) were male. The central macular thickness (CMT) in the exudative PNV group was significantly higher than that in the non-exudative PNV group (383.97±132.16 µm vs 213.13±51.63 µm; P<0.001). The maximum height of flat irregular pigment epithelial detachments (FIPED) was 45.40±11.86 μm in the non-exudative PNV group, significantly lower than the 71.58±20.91 μm (P<0.001) in the exudative PNV group. The area of PNV of the non-exudative PNV group was, significantly larger than that of the exudative PNV group (1.06±0.84 mm2 vs 0.63±0.80 mm2, P=0.016). There was a significant difference in PNV morphology between the two groups (P<0.001). Multivariate logistic regression analysis found that the maximum height of FIPED (OR=1.156, 95%CI: 1.019-1.312; P=0.024) and microvascular branches (OR=69.412, 95%CI: 3.538-1361.844; P=0.005) were independent predictors of PNV activity. CONCLUSION: The OCTA imaging finds that there are significant differences in CMT, maximum height of FIPED, PNV area, and morphology of exudative PNV and non-exudative PNV groups. OCTA can accurately identify the clinical and imaging features of exudative and non-exudative treatment-naïve PNV, and distinguish PNV activity.http://ies.ijo.cn/en_publish/2023/12/20231215.pdfoptical coherence tomography angiographypachychoroid neovasculopathytype 1 choroidal neovascularization |
| spellingShingle | Chun Yang Zu-Hua Sun Ting-Ye Zhou Wei-Wei Zheng Xiao-Ling Liu Bing Lin Optical coherence tomography angiography characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy International Journal of Ophthalmology optical coherence tomography angiography pachychoroid neovasculopathy type 1 choroidal neovascularization |
| title | Optical coherence tomography angiography characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy |
| title_full | Optical coherence tomography angiography characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy |
| title_fullStr | Optical coherence tomography angiography characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy |
| title_full_unstemmed | Optical coherence tomography angiography characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy |
| title_short | Optical coherence tomography angiography characteristics of exudative and non-exudative treatment-naïve pachychoroid neovasculopathy |
| title_sort | optical coherence tomography angiography characteristics of exudative and non exudative treatment naive pachychoroid neovasculopathy |
| topic | optical coherence tomography angiography pachychoroid neovasculopathy type 1 choroidal neovascularization |
| url | http://ies.ijo.cn/en_publish/2023/12/20231215.pdf |
| work_keys_str_mv | AT chunyang opticalcoherencetomographyangiographycharacteristicsofexudativeandnonexudativetreatmentnaivepachychoroidneovasculopathy AT zuhuasun opticalcoherencetomographyangiographycharacteristicsofexudativeandnonexudativetreatmentnaivepachychoroidneovasculopathy AT tingyezhou opticalcoherencetomographyangiographycharacteristicsofexudativeandnonexudativetreatmentnaivepachychoroidneovasculopathy AT weiweizheng opticalcoherencetomographyangiographycharacteristicsofexudativeandnonexudativetreatmentnaivepachychoroidneovasculopathy AT xiaolingliu opticalcoherencetomographyangiographycharacteristicsofexudativeandnonexudativetreatmentnaivepachychoroidneovasculopathy AT binglin opticalcoherencetomographyangiographycharacteristicsofexudativeandnonexudativetreatmentnaivepachychoroidneovasculopathy |