Functional Enrichment Analysis of Tumor Microenvironment–Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis
Nowadays, hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths, and identifying the effective factors in causing this disease can play an important role in its prevention and treatment. Tumors provide effective agents for invasion and metastasis to other organs by establishing...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-02-01
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| Series: | Bioinformatics and Biology Insights |
| Online Access: | https://doi.org/10.1177/11779322241227722 |
| _version_ | 1797324258477604864 |
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| author | Mahnaz Abdolahi Parnian Ghaedi Talkhounche Mohammad Hossein Derakhshan Nazari Haniyeh Sadat Hosseininia Niloofar Khoshdel-Rad Amin Ebrahimi Sadrabadi |
| author_facet | Mahnaz Abdolahi Parnian Ghaedi Talkhounche Mohammad Hossein Derakhshan Nazari Haniyeh Sadat Hosseininia Niloofar Khoshdel-Rad Amin Ebrahimi Sadrabadi |
| author_sort | Mahnaz Abdolahi |
| collection | DOAJ |
| description | Nowadays, hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths, and identifying the effective factors in causing this disease can play an important role in its prevention and treatment. Tumors provide effective agents for invasion and metastasis to other organs by establishing appropriate communication between cancer cells and the microenvironment. Epithelial-to-mesenchymal transition (EMT) can be mentioned as one of the effective phenomena in tumor invasion and metastasis. Several factors are involved in inducing this phenomenon in the tumor microenvironment, which helps the tumor survive and migrate to other places. It can be effective to identify these factors in the use of appropriate treatment strategies and greater patient survival. This study investigated the molecular differences between tumor border cells and tumor core cells or internal tumor cells in HCC for specific EMT genes. Expression of NOTCH1, ID1, and LST1 genes showed a significant increase at the HCC tumor border. Targeting these genes can be considered as a useful therapeutic strategy to prevent distant metastasis in HCC patients. |
| first_indexed | 2024-03-08T05:53:30Z |
| format | Article |
| id | doaj.art-4871b24674a54e55a268a728ea968dd0 |
| institution | Directory Open Access Journal |
| issn | 1177-9322 |
| language | English |
| last_indexed | 2024-03-08T05:53:30Z |
| publishDate | 2024-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Bioinformatics and Biology Insights |
| spelling | doaj.art-4871b24674a54e55a268a728ea968dd02024-02-05T06:03:22ZengSAGE PublishingBioinformatics and Biology Insights1177-93222024-02-011810.1177/11779322241227722Functional Enrichment Analysis of Tumor Microenvironment–Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant MetastasisMahnaz Abdolahi0Parnian Ghaedi Talkhounche1Mohammad Hossein Derakhshan Nazari2Haniyeh Sadat Hosseininia3Niloofar Khoshdel-Rad4Amin Ebrahimi Sadrabadi5Department of Immunology, Faculty of Medicine, Shahid Beheshti University, Tehran, IranDepartment of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, IranDepartment of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, IranCytotech & Bioinformatics Research Group, Bioinformatics Department, Tehran, IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACER, Tehran, IranNowadays, hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths, and identifying the effective factors in causing this disease can play an important role in its prevention and treatment. Tumors provide effective agents for invasion and metastasis to other organs by establishing appropriate communication between cancer cells and the microenvironment. Epithelial-to-mesenchymal transition (EMT) can be mentioned as one of the effective phenomena in tumor invasion and metastasis. Several factors are involved in inducing this phenomenon in the tumor microenvironment, which helps the tumor survive and migrate to other places. It can be effective to identify these factors in the use of appropriate treatment strategies and greater patient survival. This study investigated the molecular differences between tumor border cells and tumor core cells or internal tumor cells in HCC for specific EMT genes. Expression of NOTCH1, ID1, and LST1 genes showed a significant increase at the HCC tumor border. Targeting these genes can be considered as a useful therapeutic strategy to prevent distant metastasis in HCC patients.https://doi.org/10.1177/11779322241227722 |
| spellingShingle | Mahnaz Abdolahi Parnian Ghaedi Talkhounche Mohammad Hossein Derakhshan Nazari Haniyeh Sadat Hosseininia Niloofar Khoshdel-Rad Amin Ebrahimi Sadrabadi Functional Enrichment Analysis of Tumor Microenvironment–Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis Bioinformatics and Biology Insights |
| title | Functional Enrichment Analysis of Tumor Microenvironment–Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis |
| title_full | Functional Enrichment Analysis of Tumor Microenvironment–Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis |
| title_fullStr | Functional Enrichment Analysis of Tumor Microenvironment–Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis |
| title_full_unstemmed | Functional Enrichment Analysis of Tumor Microenvironment–Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis |
| title_short | Functional Enrichment Analysis of Tumor Microenvironment–Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis |
| title_sort | functional enrichment analysis of tumor microenvironment driven molecular alterations that facilitate epithelial to mesenchymal transition and distant metastasis |
| url | https://doi.org/10.1177/11779322241227722 |
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