Infection with Non-Lethal West Nile Virus Eg101 Strain Induces Immunity that Protects Mice against the Lethal West Nile Virus NY99 Strain

Infection with Non-Lethal West Nile Virus Eg101 Strain Induces Immunity that Protects Mice against the Lethal West Nile Virus NY99 Strain

Herein we demonstrate that infection of mice with West Nile virus (WNV) Eg101 provides protective immunity against lethal challenge with WNV NY99. Our data demonstrated that WNV Eg101 is largely non-virulent in adult mice when compared to WNV NY99. By day 6 after infection, WNV-specific IgM and IgG...

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Bibliographic Details
Main Authors: Mukesh Kumar, Maile O'Connell, Madhuri Namekar, Vivek R. Nerurkar
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Viruses
Subjects:
West Nile virus
flavivirus
WNV NY99
WNV Eg101
encephalitis
humoral immunity
vaccine
Online Access:http://www.mdpi.com/1999-4915/6/6/2328

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