Hyperthyroidism Is Associated with the Development of Vasospastic Angina, but Not with Cardiovascular Outcomes
Vasospastic angina (VA) is a functional disease caused by the alteration of vasomotor tone. We investigated the association of hyperthyroidism with the development and prognosis of VA. Study data were obtained from a prospective multicenter registry that included patients who had symptoms suggestive...
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MDPI AG
2020-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/9/3020 |
| _version_ | 1797553232579395584 |
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| author | Hyun-Jin Kim Sang-Ho Jo Min-Ho Lee Won-Woo Seo Sang Hong Baek |
| author_facet | Hyun-Jin Kim Sang-Ho Jo Min-Ho Lee Won-Woo Seo Sang Hong Baek |
| author_sort | Hyun-Jin Kim |
| collection | DOAJ |
| description | Vasospastic angina (VA) is a functional disease caused by the alteration of vasomotor tone. We investigated the association of hyperthyroidism with the development and prognosis of VA. Study data were obtained from a prospective multicenter registry that included patients who had symptoms suggestive of VA. Coronary angiography and an ergonovine provocation test were performed, and patients were classified into a VA and a non-VA group. Among 1239 patients with suspected VA, 831 patients were classified in the VA group. Hyperthyroidism was more common in the VA group than in the non-VA group (10.0% vs. 3.7%, <i>p</i> < 0.001). After adjusting for confounding factors, hyperthyroidism was independently associated with a 3.27-fold increased risk of VA. Especially in women, hyperthyroidism was associated with a 4.38-fold higher risk of VA. All-cause death rates did not differ according to the presence or absence of hyperthyroidism. Hyperthyroidism is independently associated with the occurrence of VA especially in women but did not affect the total death in VA patients. Clinicians need to be aware of the role of thyroid function in patients with suspected VA. |
| first_indexed | 2024-03-10T16:12:28Z |
| format | Article |
| id | doaj.art-487408eaf4fd4a3cba39dfb56ef157f9 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T16:12:28Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-487408eaf4fd4a3cba39dfb56ef157f92023-11-20T14:20:25ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-0199302010.3390/jcm9093020Hyperthyroidism Is Associated with the Development of Vasospastic Angina, but Not with Cardiovascular OutcomesHyun-Jin Kim0Sang-Ho Jo1Min-Ho Lee2Won-Woo Seo3Sang Hong Baek4Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul 04763, KoreaDivision of Cardiology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang-si 14068, KoreaDivision of Cardiology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, KoreaDivision of Cardiology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 05355, KoreaDivision of Cardiology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul 06591, KoreaVasospastic angina (VA) is a functional disease caused by the alteration of vasomotor tone. We investigated the association of hyperthyroidism with the development and prognosis of VA. Study data were obtained from a prospective multicenter registry that included patients who had symptoms suggestive of VA. Coronary angiography and an ergonovine provocation test were performed, and patients were classified into a VA and a non-VA group. Among 1239 patients with suspected VA, 831 patients were classified in the VA group. Hyperthyroidism was more common in the VA group than in the non-VA group (10.0% vs. 3.7%, <i>p</i> < 0.001). After adjusting for confounding factors, hyperthyroidism was independently associated with a 3.27-fold increased risk of VA. Especially in women, hyperthyroidism was associated with a 4.38-fold higher risk of VA. All-cause death rates did not differ according to the presence or absence of hyperthyroidism. Hyperthyroidism is independently associated with the occurrence of VA especially in women but did not affect the total death in VA patients. Clinicians need to be aware of the role of thyroid function in patients with suspected VA.https://www.mdpi.com/2077-0383/9/9/3020vasospastic anginahyperthyroidismclinical outcomes |
| spellingShingle | Hyun-Jin Kim Sang-Ho Jo Min-Ho Lee Won-Woo Seo Sang Hong Baek Hyperthyroidism Is Associated with the Development of Vasospastic Angina, but Not with Cardiovascular Outcomes Journal of Clinical Medicine vasospastic angina hyperthyroidism clinical outcomes |
| title | Hyperthyroidism Is Associated with the Development of Vasospastic Angina, but Not with Cardiovascular Outcomes |
| title_full | Hyperthyroidism Is Associated with the Development of Vasospastic Angina, but Not with Cardiovascular Outcomes |
| title_fullStr | Hyperthyroidism Is Associated with the Development of Vasospastic Angina, but Not with Cardiovascular Outcomes |
| title_full_unstemmed | Hyperthyroidism Is Associated with the Development of Vasospastic Angina, but Not with Cardiovascular Outcomes |
| title_short | Hyperthyroidism Is Associated with the Development of Vasospastic Angina, but Not with Cardiovascular Outcomes |
| title_sort | hyperthyroidism is associated with the development of vasospastic angina but not with cardiovascular outcomes |
| topic | vasospastic angina hyperthyroidism clinical outcomes |
| url | https://www.mdpi.com/2077-0383/9/9/3020 |
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