Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation

Generation of Angiotensin-Converting Enzyme 2/Transmembrane Protease Serine 2-Double-Positive Human Induced Pluripotent Stem Cell-Derived Spheroids for Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Drug Evaluation

ABSTRACT We newly generated two human induced pluripotent stem cell (hiPSC)-derived spheroid lines, termed Spheroids_4MACE2-TMPRSS2 and Spheroids_15M63ACE2-TMPRSS2, both of which express angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2), which are critical for seve...

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Bibliographic Details
Main Authors: Nobuyo Higashi-Kuwata, Shigeharu G. Yabe, Satsuki Fukuda, Junko Nishida, Miwa Tamura-Nakano, Shin-ichiro Hattori, Hitoshi Okochi, Hiroaki Mitsuya
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
COVID-19
SARS-CoV-2
TMPRSS2
hACE2
hiPSC-derived spheroids
in vitro drug evaluation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03490-22

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