Autologous Platelet-Rich Plasma Improves Pregnancy Outcomes of Patients with Thin Endometrium Regardless Endometrial Thickening: Multicenter Retrospective Study with Elimination of Embryonic Confounders
Objective: To determine whether endometrial thickening is an important factor for pregnancy outcomes in platelet-rich plasma (PRP) treatment for patients with thin endometrium. Methods: Data from the registry database of the Japan Gynecologic PRP Study Group from April 2019 to October 2021 were anal...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing
2023-03-01
|
| Series: | Fertility & Reproduction |
| Subjects: | |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661318223500020 |
| _version_ | 1797236989922115584 |
|---|---|
| author | Satoshi Suzuki Maki Kusumi Tomoko Maeda Kiyotaka Kawai Toshihiro Kawamura Eri Okamoto Toushun Jo Ryo Tsutsumi Satoru Takamizawa Takahiro Nakayama Motowo Nabeta Yukio Nishiyama Mari Nomiyama Kenji Furui Yoshiharu Morimoto Osamu Tsutsumi |
| author_facet | Satoshi Suzuki Maki Kusumi Tomoko Maeda Kiyotaka Kawai Toshihiro Kawamura Eri Okamoto Toushun Jo Ryo Tsutsumi Satoru Takamizawa Takahiro Nakayama Motowo Nabeta Yukio Nishiyama Mari Nomiyama Kenji Furui Yoshiharu Morimoto Osamu Tsutsumi |
| author_sort | Satoshi Suzuki |
| collection | DOAJ |
| description | Objective: To determine whether endometrial thickening is an important factor for pregnancy outcomes in platelet-rich plasma (PRP) treatment for patients with thin endometrium. Methods: Data from the registry database of the Japan Gynecologic PRP Study Group from April 2019 to October 2021 were analyzed retrospectively. A total of 208 patients who underwent single blastocyst transfer (SBT) after PRP due to thin endometrium (¡8 mm) in their previous cycle were included in the study. Their pregnancy outcomes were compared with their own historical data before PRP infusion. The same patient group was then divided into 136 patients whose endometrium thickened after PRP and 72 patients whose endometrium did not, and the pregnancy outcomes of the two groups were compared. Furthermore, to eliminate embryonic confounding, 28 patients who had single euploid blastocyst transfer (SEBT) with preimplantation genetic testing for aneuploidy (PGT-A) were selected from the same patient group and divided into two groups of 22 patients whose endometrium thickened and 6 patients whose endometrium did not, and the pregnancy outcomes were compared in the same method. Results: After PRP administration, the clinical pregnancy rate, live birth rate, and miscarriage rate were all significantly improved compared with the historical controls (34.1 vs 20.0, [Formula: see text]; 22.6 vs 3.9, [Formula: see text]; 33.8 vs 73.4, [Formula: see text]). There were no statistically significant differences in the respective rates between the “thickened endometrium” group and the “unthickened endometrium” group in SBT group (36.0 vs [Formula: see text], [Formula: see text]; 25.7 vs [Formula: see text], [Formula: see text]; 28.5 vs [Formula: see text], [Formula: see text], respectively). Likewise, in the SEBT with PGT-A group, there were no statistically significant differences in results between the two groups (36.4 vs [Formula: see text], [Formula: see text]; 36.4 vs [Formula: see text], [Formula: see text]; 0 vs [Formula: see text], respectively). Conclusions: PRP administration to patients with thin endometrium improves pregnancy outcomes even when endometrial thickening is not achieved. |
| first_indexed | 2024-04-24T17:12:37Z |
| format | Article |
| id | doaj.art-4875a5fbe84c4bcebbdde244ff041553 |
| institution | Directory Open Access Journal |
| issn | 2661-3182 2661-3174 |
| language | English |
| last_indexed | 2024-04-24T17:12:37Z |
| publishDate | 2023-03-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Fertility & Reproduction |
| spelling | doaj.art-4875a5fbe84c4bcebbdde244ff0415532024-03-28T08:43:40ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742023-03-010501212810.1142/S2661318223500020Autologous Platelet-Rich Plasma Improves Pregnancy Outcomes of Patients with Thin Endometrium Regardless Endometrial Thickening: Multicenter Retrospective Study with Elimination of Embryonic ConfoundersSatoshi Suzuki0Maki Kusumi1Tomoko Maeda2Kiyotaka Kawai3Toshihiro Kawamura4Eri Okamoto5Toushun Jo6Ryo Tsutsumi7Satoru Takamizawa8Takahiro Nakayama9Motowo Nabeta10Yukio Nishiyama11Mari Nomiyama12Kenji Furui13Yoshiharu Morimoto14Osamu Tsutsumi15Center for Human Reproduction and Gynecologic Endoscopy, Sanno Hospital, Tokyo, JapanCenter for Human Reproduction and Gynecologic Endoscopy, Sanno Hospital, Tokyo, JapanOchi Yume Clinic Nagoya, Aichi, JapanDepartment of Reproductive Medicine, Kameda IVF Clinic Makuhari, Chiba, JapanDenentoshi Ladies Clinic, Kanagawa, JapanHanabusa Women’s Clinic, Hyogo, JapanJo Clinic, Hyogo, JapanCenter for Reproductive Medicine and Endoscopy, Sugiyama Clinic Marunouchi, Tokyo, JapanSugiyama Clinic Shinjuku, Tokyo, JapanAdachi Hospital, Kyoto, JapanTsubaki Women’s Clinic, Ehime, JapanMedical Corporation, Nishiyama Obstetrics and Gynecology Clinic, Mie, JapanDepartment of Obstetrics & Gynecology, Takagi Hospital, Fukuoka, JapanClinic Mama, Gifu, JapanHORAC Grand Front Osaka Clinic, Osaka, JapanHonorary Director of Sanno Hospital, Tokyo, JapanObjective: To determine whether endometrial thickening is an important factor for pregnancy outcomes in platelet-rich plasma (PRP) treatment for patients with thin endometrium. Methods: Data from the registry database of the Japan Gynecologic PRP Study Group from April 2019 to October 2021 were analyzed retrospectively. A total of 208 patients who underwent single blastocyst transfer (SBT) after PRP due to thin endometrium (¡8 mm) in their previous cycle were included in the study. Their pregnancy outcomes were compared with their own historical data before PRP infusion. The same patient group was then divided into 136 patients whose endometrium thickened after PRP and 72 patients whose endometrium did not, and the pregnancy outcomes of the two groups were compared. Furthermore, to eliminate embryonic confounding, 28 patients who had single euploid blastocyst transfer (SEBT) with preimplantation genetic testing for aneuploidy (PGT-A) were selected from the same patient group and divided into two groups of 22 patients whose endometrium thickened and 6 patients whose endometrium did not, and the pregnancy outcomes were compared in the same method. Results: After PRP administration, the clinical pregnancy rate, live birth rate, and miscarriage rate were all significantly improved compared with the historical controls (34.1 vs 20.0, [Formula: see text]; 22.6 vs 3.9, [Formula: see text]; 33.8 vs 73.4, [Formula: see text]). There were no statistically significant differences in the respective rates between the “thickened endometrium” group and the “unthickened endometrium” group in SBT group (36.0 vs [Formula: see text], [Formula: see text]; 25.7 vs [Formula: see text], [Formula: see text]; 28.5 vs [Formula: see text], [Formula: see text], respectively). Likewise, in the SEBT with PGT-A group, there were no statistically significant differences in results between the two groups (36.4 vs [Formula: see text], [Formula: see text]; 36.4 vs [Formula: see text], [Formula: see text]; 0 vs [Formula: see text], respectively). Conclusions: PRP administration to patients with thin endometrium improves pregnancy outcomes even when endometrial thickening is not achieved.https://www.worldscientific.com/doi/10.1142/S2661318223500020Assisted Reproductive TechnologyFrozen Embryo TransferPlatelet-rich PlasmaPreimplantation Genetic Testing for AneuploidyRecurrent Implantation Failure |
| spellingShingle | Satoshi Suzuki Maki Kusumi Tomoko Maeda Kiyotaka Kawai Toshihiro Kawamura Eri Okamoto Toushun Jo Ryo Tsutsumi Satoru Takamizawa Takahiro Nakayama Motowo Nabeta Yukio Nishiyama Mari Nomiyama Kenji Furui Yoshiharu Morimoto Osamu Tsutsumi Autologous Platelet-Rich Plasma Improves Pregnancy Outcomes of Patients with Thin Endometrium Regardless Endometrial Thickening: Multicenter Retrospective Study with Elimination of Embryonic Confounders Fertility & Reproduction Assisted Reproductive Technology Frozen Embryo Transfer Platelet-rich Plasma Preimplantation Genetic Testing for Aneuploidy Recurrent Implantation Failure |
| title | Autologous Platelet-Rich Plasma Improves Pregnancy Outcomes of Patients with Thin Endometrium Regardless Endometrial Thickening: Multicenter Retrospective Study with Elimination of Embryonic Confounders |
| title_full | Autologous Platelet-Rich Plasma Improves Pregnancy Outcomes of Patients with Thin Endometrium Regardless Endometrial Thickening: Multicenter Retrospective Study with Elimination of Embryonic Confounders |
| title_fullStr | Autologous Platelet-Rich Plasma Improves Pregnancy Outcomes of Patients with Thin Endometrium Regardless Endometrial Thickening: Multicenter Retrospective Study with Elimination of Embryonic Confounders |
| title_full_unstemmed | Autologous Platelet-Rich Plasma Improves Pregnancy Outcomes of Patients with Thin Endometrium Regardless Endometrial Thickening: Multicenter Retrospective Study with Elimination of Embryonic Confounders |
| title_short | Autologous Platelet-Rich Plasma Improves Pregnancy Outcomes of Patients with Thin Endometrium Regardless Endometrial Thickening: Multicenter Retrospective Study with Elimination of Embryonic Confounders |
| title_sort | autologous platelet rich plasma improves pregnancy outcomes of patients with thin endometrium regardless endometrial thickening multicenter retrospective study with elimination of embryonic confounders |
| topic | Assisted Reproductive Technology Frozen Embryo Transfer Platelet-rich Plasma Preimplantation Genetic Testing for Aneuploidy Recurrent Implantation Failure |
| url | https://www.worldscientific.com/doi/10.1142/S2661318223500020 |
| work_keys_str_mv | AT satoshisuzuki autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT makikusumi autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT tomokomaeda autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT kiyotakakawai autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT toshihirokawamura autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT eriokamoto autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT toushunjo autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT ryotsutsumi autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT satorutakamizawa autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT takahironakayama autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT motowonabeta autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT yukionishiyama autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT marinomiyama autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT kenjifurui autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT yoshiharumorimoto autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders AT osamutsutsumi autologousplateletrichplasmaimprovespregnancyoutcomesofpatientswiththinendometriumregardlessendometrialthickeningmulticenterretrospectivestudywitheliminationofembryonicconfounders |