Mechanisms of group B Streptococcusmediated preterm birth: lessons learnt from animal models
Group B Streptococcus (GBS) is an opportunistic pathogenic bacterium which upon colonization in the female reproductive tract can cause preterm births, fetal injury, and demise. Several determinants for GBS pathogenesis have been explored so far through the studies using animal models ranging from m...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-07-01
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| Series: | Vascular Biology |
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| Online Access: | https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-21-0105.xml |
| _version_ | 1818466222823440384 |
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| author | Noble K Kurian Deepak Modi |
| author_facet | Noble K Kurian Deepak Modi |
| author_sort | Noble K Kurian |
| collection | DOAJ |
| description | Group B Streptococcus (GBS) is an opportunistic pathogenic bacterium which upon colonization in the female reproductive tract can cause preterm births, fetal injury, and demise. Several determinants for GBS pathogenesis have been explored so far through the studies using animal models ranging from mice to non-human primates. The results from these experimental data have identified outer membrane vesicles, β-hemolysin, hyaluronidase, and Cas9 of GBS as major virulence factors leading to preterm births. Most of these factors drive inflammation through activation of NLRP3 and elevated production of IL1-β. However, the absence of one of the factors from the pathogen reduces but does not completely abolish the pathogenesis of GBS suggesting the involvement of more than one factor in causing preterm birth. This makes further exploration of other virulence factors of GBS pathogenesis important in gaining an insight into the mechanistic basis of GBS-mediated preterm births. |
| first_indexed | 2024-04-13T20:56:09Z |
| format | Article |
| id | doaj.art-4876dd222a31460b8005f280fde60f5e |
| institution | Directory Open Access Journal |
| issn | 2516-5658 |
| language | English |
| last_indexed | 2024-04-13T20:56:09Z |
| publishDate | 2022-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Vascular Biology |
| spelling | doaj.art-4876dd222a31460b8005f280fde60f5e2022-12-22T02:30:19ZengBioscientificaVascular Biology2516-56582022-07-0133R109R120https://doi.org/10.1530/RAF-21-0105Mechanisms of group B Streptococcusmediated preterm birth: lessons learnt from animal modelsNoble K Kurian0Deepak Modi1Department of Microbiology, Atmiya University, Rajkot, Gujarat, IndiaMolecular and Cellular Biology Laboratory, ICMR-National Institute for Research in Reproductive Health and Child Health (NIRRCH), Indian Council of Medical Research (ICMR), Mumbai, IndiaGroup B Streptococcus (GBS) is an opportunistic pathogenic bacterium which upon colonization in the female reproductive tract can cause preterm births, fetal injury, and demise. Several determinants for GBS pathogenesis have been explored so far through the studies using animal models ranging from mice to non-human primates. The results from these experimental data have identified outer membrane vesicles, β-hemolysin, hyaluronidase, and Cas9 of GBS as major virulence factors leading to preterm births. Most of these factors drive inflammation through activation of NLRP3 and elevated production of IL1-β. However, the absence of one of the factors from the pathogen reduces but does not completely abolish the pathogenesis of GBS suggesting the involvement of more than one factor in causing preterm birth. This makes further exploration of other virulence factors of GBS pathogenesis important in gaining an insight into the mechanistic basis of GBS-mediated preterm births.https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-21-0105.xmlstreptococcus agalactiaepathogenesisinfectionmembrane ruptureanimal modelpregnancy |
| spellingShingle | Noble K Kurian Deepak Modi Mechanisms of group B Streptococcusmediated preterm birth: lessons learnt from animal models Vascular Biology streptococcus agalactiae pathogenesis infection membrane rupture animal model pregnancy |
| title | Mechanisms of group B Streptococcusmediated preterm birth: lessons learnt from animal models |
| title_full | Mechanisms of group B Streptococcusmediated preterm birth: lessons learnt from animal models |
| title_fullStr | Mechanisms of group B Streptococcusmediated preterm birth: lessons learnt from animal models |
| title_full_unstemmed | Mechanisms of group B Streptococcusmediated preterm birth: lessons learnt from animal models |
| title_short | Mechanisms of group B Streptococcusmediated preterm birth: lessons learnt from animal models |
| title_sort | mechanisms of group b streptococcusmediated preterm birth lessons learnt from animal models |
| topic | streptococcus agalactiae pathogenesis infection membrane rupture animal model pregnancy |
| url | https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-21-0105.xml |
| work_keys_str_mv | AT noblekkurian mechanismsofgroupbstreptococcusmediatedpretermbirthlessonslearntfromanimalmodels AT deepakmodi mechanismsofgroupbstreptococcusmediatedpretermbirthlessonslearntfromanimalmodels |