Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10
Spindle cell lipoma (SCL), also called as pleomorphic adenoma, is a rare variant of lipoma histopathologically characterized by an admixture of mature fat cells with spindle cells and occasionally mast cells with myxoid connective tissue stroma and thick bends of birefringent collagen. Although bucc...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=4;spage=561;epage=563;aulast=Bajpai |
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| author | Manas Bajpai Nilesh Pardhe Manish Kumar |
| author_facet | Manas Bajpai Nilesh Pardhe Manish Kumar |
| author_sort | Manas Bajpai |
| collection | DOAJ |
| description | Spindle cell lipoma (SCL), also called as pleomorphic adenoma, is a rare variant of lipoma histopathologically characterized by an admixture of mature fat cells with spindle cells and occasionally mast cells with myxoid connective tissue stroma and thick bends of birefringent collagen. Although buccal mucosa is the most common location for oral lipomas, for SCL, it is an exceedingly rare location. We report a case of an asymptomatic swelling of buccal mucosa that simulated the features of neurofibroma on histopathological examination, and the final diagnosis of SCL was made on the basis of immunohistochemical features. This is the first documentation of oral SCL using SOX10 to achieve the final diagnosis. |
| first_indexed | 2024-12-21T09:40:18Z |
| format | Article |
| id | doaj.art-4877e9dc52694d719ddeb1a580be0708 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-21T09:40:18Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-4877e9dc52694d719ddeb1a580be07082022-12-21T19:08:29ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292018-01-0161456156310.4103/IJPM.IJPM_473_17Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10Manas BajpaiNilesh PardheManish KumarSpindle cell lipoma (SCL), also called as pleomorphic adenoma, is a rare variant of lipoma histopathologically characterized by an admixture of mature fat cells with spindle cells and occasionally mast cells with myxoid connective tissue stroma and thick bends of birefringent collagen. Although buccal mucosa is the most common location for oral lipomas, for SCL, it is an exceedingly rare location. We report a case of an asymptomatic swelling of buccal mucosa that simulated the features of neurofibroma on histopathological examination, and the final diagnosis of SCL was made on the basis of immunohistochemical features. This is the first documentation of oral SCL using SOX10 to achieve the final diagnosis.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=4;spage=561;epage=563;aulast=BajpaiCD34connective tissue tumorneurofibromasoft-tissue tumorSOX10spindle cell lipoma |
| spellingShingle | Manas Bajpai Nilesh Pardhe Manish Kumar Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10 Indian Journal of Pathology and Microbiology CD34 connective tissue tumor neurofibroma soft-tissue tumor SOX10 spindle cell lipoma |
| title | Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10 |
| title_full | Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10 |
| title_fullStr | Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10 |
| title_full_unstemmed | Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10 |
| title_short | Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10 |
| title_sort | immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using cd34 and sox10 |
| topic | CD34 connective tissue tumor neurofibroma soft-tissue tumor SOX10 spindle cell lipoma |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=4;spage=561;epage=563;aulast=Bajpai |
| work_keys_str_mv | AT manasbajpai immunohistochemicaldifferentiationbetweenspindlecelllipomaandneurofibromaoforalcavityusingcd34andsox10 AT nileshpardhe immunohistochemicaldifferentiationbetweenspindlecelllipomaandneurofibromaoforalcavityusingcd34andsox10 AT manishkumar immunohistochemicaldifferentiationbetweenspindlecelllipomaandneurofibromaoforalcavityusingcd34andsox10 |