Helicobacter pylori and colorectal neoplasms: a concise review
ABSTRACT Helicobacter pylori is the main etiological agent of all malignant tumors caused by an infectious disease. It is a major, at times dominant, factor in the pathogenesis of a large spectrum of diseases such as acute and chronic gastritis, gastric and duodenal ulcers, gastric carcinoma, and ly...
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| Format: | Article |
| Language: | English |
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
2021-04-01
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| Series: | Arquivos de Gastroenterologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032021000100114&tlng=en |
| _version_ | 1828126582248570880 |
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| author | Luiz Gonzaga Vaz COELHO Maria Clara Freitas COELHO |
| author_facet | Luiz Gonzaga Vaz COELHO Maria Clara Freitas COELHO |
| author_sort | Luiz Gonzaga Vaz COELHO |
| collection | DOAJ |
| description | ABSTRACT Helicobacter pylori is the main etiological agent of all malignant tumors caused by an infectious disease. It is a major, at times dominant, factor in the pathogenesis of a large spectrum of diseases such as acute and chronic gastritis, gastric and duodenal ulcers, gastric carcinoma, and lymphoma. Epidemiological and experimental studies suggest that H. pylori chronic infection may be related to different extragastric diseases, including colorectal neoplasms. This concise review aims to explore the association of H. pylori infection with colorectal cancer and adenoma, including the recent epidemiological findings, the diagnostic methods employed to detect H. pylori and virulent factors, and the potentially involved mechanisms. Furthermore, is attempted to establish the current data integration for causal inference using the Bradford-Hill causality criteria. The weak, although global, strength of the epidemiological positive association between H. pylori infection and colonic neoplasms associated to new mechanisms postulated to explain this interaction, including intestinal dysbiosis, should stimulate future studies. Prospective confirmatory studies to establish the role of H. pylori eradication in the process of carcinogenic transformation of the colonic epithelium may define its eventual role in the treatment and prevention of colonic neoplasms. |
| first_indexed | 2024-04-11T15:38:03Z |
| format | Article |
| id | doaj.art-487aa79c546143538cf738a12c4d1ba3 |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-04-11T15:38:03Z |
| publishDate | 2021-04-01 |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-487aa79c546143538cf738a12c4d1ba32022-12-22T04:15:55ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-42192021-04-0158111411910.1590/s0004-2803.202100000-19Helicobacter pylori and colorectal neoplasms: a concise reviewLuiz Gonzaga Vaz COELHOhttps://orcid.org/0000-0002-8721-7696Maria Clara Freitas COELHOhttps://orcid.org/0000-0001-8028-6114ABSTRACT Helicobacter pylori is the main etiological agent of all malignant tumors caused by an infectious disease. It is a major, at times dominant, factor in the pathogenesis of a large spectrum of diseases such as acute and chronic gastritis, gastric and duodenal ulcers, gastric carcinoma, and lymphoma. Epidemiological and experimental studies suggest that H. pylori chronic infection may be related to different extragastric diseases, including colorectal neoplasms. This concise review aims to explore the association of H. pylori infection with colorectal cancer and adenoma, including the recent epidemiological findings, the diagnostic methods employed to detect H. pylori and virulent factors, and the potentially involved mechanisms. Furthermore, is attempted to establish the current data integration for causal inference using the Bradford-Hill causality criteria. The weak, although global, strength of the epidemiological positive association between H. pylori infection and colonic neoplasms associated to new mechanisms postulated to explain this interaction, including intestinal dysbiosis, should stimulate future studies. Prospective confirmatory studies to establish the role of H. pylori eradication in the process of carcinogenic transformation of the colonic epithelium may define its eventual role in the treatment and prevention of colonic neoplasms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032021000100114&tlng=enHelicobacter infectionsColorectal neoplasmsAdenomaEpidemiologic factors |
| spellingShingle | Luiz Gonzaga Vaz COELHO Maria Clara Freitas COELHO Helicobacter pylori and colorectal neoplasms: a concise review Arquivos de Gastroenterologia Helicobacter infections Colorectal neoplasms Adenoma Epidemiologic factors |
| title | Helicobacter pylori and colorectal neoplasms: a concise review |
| title_full | Helicobacter pylori and colorectal neoplasms: a concise review |
| title_fullStr | Helicobacter pylori and colorectal neoplasms: a concise review |
| title_full_unstemmed | Helicobacter pylori and colorectal neoplasms: a concise review |
| title_short | Helicobacter pylori and colorectal neoplasms: a concise review |
| title_sort | helicobacter pylori and colorectal neoplasms a concise review |
| topic | Helicobacter infections Colorectal neoplasms Adenoma Epidemiologic factors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032021000100114&tlng=en |
| work_keys_str_mv | AT luizgonzagavazcoelho helicobacterpyloriandcolorectalneoplasmsaconcisereview AT mariaclarafreitascoelho helicobacterpyloriandcolorectalneoplasmsaconcisereview |