Progressive ectropion uveae and secondary angle-closure glaucoma in type 1 neurofibromatosis
Purpose: To present a case of progressive ectropion uveae and secondary angle-closure glaucoma in association with type 1 neurofibromatosis (NF-1). Observation: An 11-year-old-Hispanic-male with a known history of NF-1 who was followed for the ocular manifestations of NF-1 developed an irregular pup...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993622000913 |
| _version_ | 1819282878755766272 |
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| author | Hamed Esfandiari Janice Lasky Zeid Angelo P. Tanna |
| author_facet | Hamed Esfandiari Janice Lasky Zeid Angelo P. Tanna |
| author_sort | Hamed Esfandiari |
| collection | DOAJ |
| description | Purpose: To present a case of progressive ectropion uveae and secondary angle-closure glaucoma in association with type 1 neurofibromatosis (NF-1). Observation: An 11-year-old-Hispanic-male with a known history of NF-1 who was followed for the ocular manifestations of NF-1 developed an irregular pupil and ectropion uveae in the right eye at the age of 3 years that gradually increased in severity. The area of ectropion uveae increased in size and extended superiorly with concurrent superior synechial angle closure and intraocular pressure (IOP) elevation. The patient subsequently developed chronic angle-closure glaucoma that could not be controlled with medical therapy. He underwent successful implantation of an aqueous drainage device which resulted in excellent intraocular pressure reduction. Conclusions and Importance: Ectropion uveae can be progressive and lead to the development of extensive angle closure in patients with NF-1. Despite the low incidence of glaucoma in patients with NF-1, the presence of ectropion uveae in this condition necessitates careful observation of the anterior segment, including the anterior chamber angle and close monitoring of the IOP. |
| first_indexed | 2024-12-24T01:22:35Z |
| format | Article |
| id | doaj.art-487b555f68c2489da6b6a2c98e54d067 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-24T01:22:35Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-487b555f68c2489da6b6a2c98e54d0672022-12-21T17:22:36ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362022-03-0125101345Progressive ectropion uveae and secondary angle-closure glaucoma in type 1 neurofibromatosisHamed Esfandiari0Janice Lasky Zeid1Angelo P. Tanna2Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USADepartment of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Corresponding author. Department of Ophthalmology, Northwestern University Feinberg School of Medicine, 645 N. Michigan Ave., Suite 440 , Chicago, IL 60611, USA.Purpose: To present a case of progressive ectropion uveae and secondary angle-closure glaucoma in association with type 1 neurofibromatosis (NF-1). Observation: An 11-year-old-Hispanic-male with a known history of NF-1 who was followed for the ocular manifestations of NF-1 developed an irregular pupil and ectropion uveae in the right eye at the age of 3 years that gradually increased in severity. The area of ectropion uveae increased in size and extended superiorly with concurrent superior synechial angle closure and intraocular pressure (IOP) elevation. The patient subsequently developed chronic angle-closure glaucoma that could not be controlled with medical therapy. He underwent successful implantation of an aqueous drainage device which resulted in excellent intraocular pressure reduction. Conclusions and Importance: Ectropion uveae can be progressive and lead to the development of extensive angle closure in patients with NF-1. Despite the low incidence of glaucoma in patients with NF-1, the presence of ectropion uveae in this condition necessitates careful observation of the anterior segment, including the anterior chamber angle and close monitoring of the IOP.http://www.sciencedirect.com/science/article/pii/S2451993622000913Ectropion uveaeNeurofibromatosis type 1Glaucoma |
| spellingShingle | Hamed Esfandiari Janice Lasky Zeid Angelo P. Tanna Progressive ectropion uveae and secondary angle-closure glaucoma in type 1 neurofibromatosis American Journal of Ophthalmology Case Reports Ectropion uveae Neurofibromatosis type 1 Glaucoma |
| title | Progressive ectropion uveae and secondary angle-closure glaucoma in type 1 neurofibromatosis |
| title_full | Progressive ectropion uveae and secondary angle-closure glaucoma in type 1 neurofibromatosis |
| title_fullStr | Progressive ectropion uveae and secondary angle-closure glaucoma in type 1 neurofibromatosis |
| title_full_unstemmed | Progressive ectropion uveae and secondary angle-closure glaucoma in type 1 neurofibromatosis |
| title_short | Progressive ectropion uveae and secondary angle-closure glaucoma in type 1 neurofibromatosis |
| title_sort | progressive ectropion uveae and secondary angle closure glaucoma in type 1 neurofibromatosis |
| topic | Ectropion uveae Neurofibromatosis type 1 Glaucoma |
| url | http://www.sciencedirect.com/science/article/pii/S2451993622000913 |
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