Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain

Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain

Notch signalling is a well-established pathway that regulates neurogenesis. However, little is known about the role of Notch signalling in specific neuronal differentiation. Using Dll1 null mice, we found that Notch signalling has no function in the specification of mesencephalic dopaminergic neural...

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Bibliographic Details
Main Authors: Niurka Trujillo-Paredes, Concepción Valencia, Gilda Guerrero-Flores, Dulce-María Arzate, José-Manuel Baizabal, Magdalena Guerra-Crespo, Ayari Fuentes-Hernández, Iván Zea-Armenta, Luis Covarrubias
Format: Article
Language:English
Published: The Company of Biologists 2016-03-01
Series:Biology Open
Subjects:
Delta-like 1
Notch
Neurogenesis
Dopaminergic neurons
Online Access:http://bio.biologists.org/content/5/3/336

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