颗粒蛋白前体在神经系统疾病中的研究进展 Progress of Role of Progranulin in Nervous System Diseases
【摘要】 颗粒蛋白前体（progranulin，PGRN）是一种多功能的分泌型糖蛋白。其表达水平及相关基因的异常改变与神经系统炎性病变、退行性病变、变性疾病、脑中溶酶体的稳态及血脑屏障完整性密切相关，参与到多种神经系统疾病的病理过程。本文对PGRN的生物学作用及其与相关神经系统疾病的研究进展进行综述，以期为相关患者的干预及相关疾病的研究提供思路及理论依据。 【Abstract】 Progranulin (PGRN) is a multifunctional secretory glycoprotein. The abnormality in PGRN expression and rel...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Chinese Journal of Stroke
2019-07-01
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| Series: | Zhongguo cuzhong zazhi |
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| Online Access: | http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=2824 |
| _version_ | 1811290014243356672 |
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| author | 张青，张蓓，李亚军 |
| author_facet | 张青，张蓓，李亚军 |
| author_sort | 张青，张蓓，李亚军 |
| collection | DOAJ |
| description | 【摘要】 颗粒蛋白前体（progranulin，PGRN）是一种多功能的分泌型糖蛋白。其表达水平及相关基因的异常改变与神经系统炎性病变、退行性病变、变性疾病、脑中溶酶体的稳态及血脑屏障完整性密切相关，参与到多种神经系统疾病的病理过程。本文对PGRN的生物学作用及其与相关神经系统疾病的研究进展进行综述，以期为相关患者的干预及相关疾病的研究提供思路及理论依据。
【Abstract】 Progranulin (PGRN) is a multifunctional secretory glycoprotein. The abnormality in PGRN expression and related genes are closely related to nervous system inflammatory lesions, degenerative diseases, neurodegenerative diseases, brain cell lysosome homeostasis and bloodbrain barrier integrity, and PGRN is involved in various pathological processes in such diseases. This article reviewed the biological effects of PGRN and progress in the role of PGRN in some neurological diseases, to provide ideas and theoretical basis for research and treatment in some neurological diseases. |
| first_indexed | 2024-04-13T04:05:25Z |
| format | Article |
| id | doaj.art-487db2274caa4c699a386ca88334116c |
| institution | Directory Open Access Journal |
| issn | 1673-5765 |
| language | zho |
| last_indexed | 2024-04-13T04:05:25Z |
| publishDate | 2019-07-01 |
| publisher | Editorial Department of Chinese Journal of Stroke |
| record_format | Article |
| series | Zhongguo cuzhong zazhi |
| spelling | doaj.art-487db2274caa4c699a386ca88334116c2022-12-22T03:03:18ZzhoEditorial Department of Chinese Journal of StrokeZhongguo cuzhong zazhi1673-57652019-07-0114773373910.3969/j.issn.1673-5765.2019.07.016颗粒蛋白前体在神经系统疾病中的研究进展 Progress of Role of Progranulin in Nervous System Diseases张青，张蓓，李亚军0李亚军 liyajun922@sina.com【摘要】 颗粒蛋白前体（progranulin，PGRN）是一种多功能的分泌型糖蛋白。其表达水平及相关基因的异常改变与神经系统炎性病变、退行性病变、变性疾病、脑中溶酶体的稳态及血脑屏障完整性密切相关，参与到多种神经系统疾病的病理过程。本文对PGRN的生物学作用及其与相关神经系统疾病的研究进展进行综述，以期为相关患者的干预及相关疾病的研究提供思路及理论依据。 【Abstract】 Progranulin (PGRN) is a multifunctional secretory glycoprotein. The abnormality in PGRN expression and related genes are closely related to nervous system inflammatory lesions, degenerative diseases, neurodegenerative diseases, brain cell lysosome homeostasis and bloodbrain barrier integrity, and PGRN is involved in various pathological processes in such diseases. This article reviewed the biological effects of PGRN and progress in the role of PGRN in some neurological diseases, to provide ideas and theoretical basis for research and treatment in some neurological diseases.http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=2824颗粒蛋白前体神经系统疾病脑梗死血脑屏障炎症progranulinneurological diseasecerebral infarctionblood-brain barrier;inflammation |
| spellingShingle | 张青，张蓓，李亚军 颗粒蛋白前体在神经系统疾病中的研究进展 Progress of Role of Progranulin in Nervous System Diseases Zhongguo cuzhong zazhi 颗粒蛋白前体 神经系统疾病 脑梗死 血脑屏障 炎症 progranulin neurological disease cerebral infarction blood-brain barrier;inflammation |
| title | 颗粒蛋白前体在神经系统疾病中的研究进展 Progress of Role of Progranulin in Nervous System Diseases |
| title_full | 颗粒蛋白前体在神经系统疾病中的研究进展 Progress of Role of Progranulin in Nervous System Diseases |
| title_fullStr | 颗粒蛋白前体在神经系统疾病中的研究进展 Progress of Role of Progranulin in Nervous System Diseases |
| title_full_unstemmed | 颗粒蛋白前体在神经系统疾病中的研究进展 Progress of Role of Progranulin in Nervous System Diseases |
| title_short | 颗粒蛋白前体在神经系统疾病中的研究进展 Progress of Role of Progranulin in Nervous System Diseases |
| title_sort | 颗粒蛋白前体在神经系统疾病中的研究进展 progress of role of progranulin in nervous system diseases |
| topic | 颗粒蛋白前体 神经系统疾病 脑梗死 血脑屏障 炎症 progranulin neurological disease cerebral infarction blood-brain barrier;inflammation |
| url | http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=2824 |
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