Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
Abstract Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-021-01906-y |
| _version_ | 1819087639507107840 |
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| author | Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M. Kopustinskiene Jurga Bernatoniene Saeed Samarghandian |
| author_facet | Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M. Kopustinskiene Jurga Bernatoniene Saeed Samarghandian |
| author_sort | Marjan Talebi |
| collection | DOAJ |
| description | Abstract Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies. Graphic abstract |
| first_indexed | 2024-12-21T21:39:21Z |
| format | Article |
| id | doaj.art-488061fb25dc4d09b59186582dc348c4 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-21T21:39:21Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-488061fb25dc4d09b59186582dc348c42022-12-21T18:49:24ZengBMCCancer Cell International1475-28672021-04-0121112010.1186/s12935-021-01906-yEmerging cellular and molecular mechanisms underlying anticancer indications of chrysinMarjan Talebi0Mohsen Talebi1Tahereh Farkhondeh2Jesus Simal-Gandara3Dalia M. Kopustinskiene4Jurga Bernatoniene5Saeed Samarghandian6Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical SciencesDepartment of Chemistry and Biochemistry, University of Texas at ArlingtonCardiovscular Diseases Research Center, Birjand University of Medical SciencesNutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Science, University of Vigo, Ourense CampusInstitute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health SciencesInstitute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health SciencesNoncommunicable Diseases Research Center, Neyshabur University of Medical SciencesAbstract Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as well as gastrointestinal, respiratory, reproductive, ocular, and skin protective effects through modulating signaling pathway involved in apoptosis, oxidative stress, and inflammation. In the current review, we discussed the emerging cellular and molecular mechanisms underlying therapeutic indications of chrysin in various cancers. Online databases comprising Scopus, PubMed, Embase, ProQuest, Science Direct, Web of Science, and the search engine Google Scholar were searched for available and eligible research articles. The search was conducted by using MeSH terms and keywords in title, abstract, and keywords. In conclusion, experimental studies indicated that chrysin could ameliorate cancers of the breast, gastrointestinal tract, liver and hepatocytes, bladder, male and female reproductive systems, choroid, respiratory tract, thyroid, skin, eye, brain, blood cells, leukemia, osteoblast, and lymph. However, more studies are needed to enhance the bioavailability of chrysin and evaluate this agent in clinical trial studies. Graphic abstracthttps://doi.org/10.1186/s12935-021-01906-yChrysinFlavonoidsOxidative stressInflammationApoptosisMetastasis |
| spellingShingle | Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M. Kopustinskiene Jurga Bernatoniene Saeed Samarghandian Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin Cancer Cell International Chrysin Flavonoids Oxidative stress Inflammation Apoptosis Metastasis |
| title | Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin |
| title_full | Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin |
| title_fullStr | Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin |
| title_full_unstemmed | Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin |
| title_short | Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin |
| title_sort | emerging cellular and molecular mechanisms underlying anticancer indications of chrysin |
| topic | Chrysin Flavonoids Oxidative stress Inflammation Apoptosis Metastasis |
| url | https://doi.org/10.1186/s12935-021-01906-y |
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