| Summary: | Introduction: Burnout syndrome is defined as that condition characterized by emotional exhaustion, depersonalization and low personal fulfillment at work. Objective: To identify if the mean scores of emotional fatigue, depersonalization and self-realization were different based on the sociodemographic variables of the nursing staff of the Elvia Carrillo Puerto Regional Hospital during the COVID-19 pandemic in 2020. Methodology: Observational and cross-sectional study. The Maslach Burnout In-ventory questionnaire was applied to 229 nurses from Mérida, Yucatán, México selected by quotas. Results: The means of emotional fatigue, depersonalization and self-realization were 15.27 (SD: 11.4), 4.85 (SD: 4.8) and 37.4 (SD: 7.7); depersonalization showed significant differences by level of education and type of contract; self-realization and emotional fatigue showed significant differences due to the number of jobs; fatigue, depersonalization and self-realization had differences when grouped based on marital status. Conclusion: Separated people, with three or more jobs, temporary contract and with a high level of educational training showed higher scores in the burnout syndrome indicators
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