Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease

Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer’s disease

Abstract Introduction Neutrophil accumulation is a well-established feature of Alzheimer’s disease (AD) and has been linked to cognitive impairment by modulating disease-relevant neuroinflammatory and vascular pathways. Neutrophils express high levels of the oxidant-generating enzyme myeloperoxidase...

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Bibliographic Details
Main Authors: Leon C. D. Smyth, Helen C. Murray, Madison Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Bruce Mockett, Malvindar K. Singh-Bains, Vanessa K. Morris, Andrew N. Clarkson, Maurice A. Curtis, Wickliffe C. Abraham, Stephanie M. Hughes, Richard L. M. Faull, Anthony J. Kettle, Mike Dragunow, Mark B. Hampton
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Neutrophil
Neutrophil extracellular trap
Blood–brain barrier
Myeloperoxidase
Online Access:https://doi.org/10.1186/s40478-022-01347-2

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