The Lung Elastin Matrix Undergoes Rapid Degradation Upon Adult Loss of Hox5 Function

The Lung Elastin Matrix Undergoes Rapid Degradation Upon Adult Loss of Hox5 Function

Hox genes encode transcription factors that are critical for embryonic skeletal patterning and organogenesis. The Hoxa5, Hoxb5, and Hoxc5 paralogs are expressed in the lung mesenchyme and function redundantly during embryonic lung development. Conditional loss-of-function of these genes during postn...

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Bibliographic Details
Main Authors: Mu-Hang Li, Leilani M. Marty-Santos, Paul R. van Ginkel, Aubrey E. McDermott, Andrew J. Rasky, Nicholas W. Lukacs, Deneen M. Wellik
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Hox genes
lung homeostasis
extracellular matrix
distal lung fibroblasts
lung macrophages
brochopulmonary dysplasia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.767454/full

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