Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysis
BackgroundThe association between shift work, night work, and the risk of dementia are conflicting in the literature.ObjectivesThis study was performed to obtain evidence on the potential relationship between shift work, night work, and dementia.MethodsTo investigate the link between shift work, nig...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.997181/full |
| _version_ | 1811330143754387456 |
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| author | Zhen-Zhi Wang Zhen Sun Mei-Ling Zhang Kang Xiong Feng Zhou |
| author_facet | Zhen-Zhi Wang Zhen Sun Mei-Ling Zhang Kang Xiong Feng Zhou |
| author_sort | Zhen-Zhi Wang |
| collection | DOAJ |
| description | BackgroundThe association between shift work, night work, and the risk of dementia are conflicting in the literature.ObjectivesThis study was performed to obtain evidence on the potential relationship between shift work, night work, and dementia.MethodsTo investigate the link between shift work, night work, and dementia, we systematically searched PubMed, Embase, and Web of Science from inception to January 1, 2022. The eligibility of the retrieved records and extracted data were independently reviewed by two researchers. The Preferred Reporting Items for Systematic Evaluations and Meta-Analyses (PRISMA) statement was followed. STATA 16.0 was used to conduct the meta-analysis.ResultsA total of four studies involving 103,104 participants were included in this meta-analysis. Pooled results indicated that night shift workers had a 12% increased risk of dementia compared to subjects without night work (HR = 1.12, 95% CI 1.03–1.23, P = 0.094). Shift work was not significantly associated with dementia risk (HR: 1.09, 95% CI: 0.83–1.43, P = 0.546), but the effect of shift work on dementia risk appeared to increase with age, with a correlation observed among workers older than 50 years (HR = 1.31; 95% CI: 1.03–1.68, P = 0.030).ConclusionThe data presented in our study suggest that night work may be a risk factor for dementia. More prospective studies with objective exposure measurements are required to further confirm this result.Systematic review registrationhttps://doi.org/10.37766/inplasy2022.6.0079, identifier: INPLASY202260079. |
| first_indexed | 2024-04-13T15:57:10Z |
| format | Article |
| id | doaj.art-4881ea995cde420890dd74dbd48a16c1 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T15:57:10Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4881ea995cde420890dd74dbd48a16c12022-12-22T02:40:39ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-11-011310.3389/fneur.2022.997181997181Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysisZhen-Zhi Wang0Zhen Sun1Mei-Ling Zhang2Kang Xiong3Feng Zhou4The First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine, Xianyang, ChinaHengyang Medical School, University of South China, Hengyang, ChinaThe First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine, Xianyang, ChinaThe First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine, Xianyang, ChinaThe Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, ChinaBackgroundThe association between shift work, night work, and the risk of dementia are conflicting in the literature.ObjectivesThis study was performed to obtain evidence on the potential relationship between shift work, night work, and dementia.MethodsTo investigate the link between shift work, night work, and dementia, we systematically searched PubMed, Embase, and Web of Science from inception to January 1, 2022. The eligibility of the retrieved records and extracted data were independently reviewed by two researchers. The Preferred Reporting Items for Systematic Evaluations and Meta-Analyses (PRISMA) statement was followed. STATA 16.0 was used to conduct the meta-analysis.ResultsA total of four studies involving 103,104 participants were included in this meta-analysis. Pooled results indicated that night shift workers had a 12% increased risk of dementia compared to subjects without night work (HR = 1.12, 95% CI 1.03–1.23, P = 0.094). Shift work was not significantly associated with dementia risk (HR: 1.09, 95% CI: 0.83–1.43, P = 0.546), but the effect of shift work on dementia risk appeared to increase with age, with a correlation observed among workers older than 50 years (HR = 1.31; 95% CI: 1.03–1.68, P = 0.030).ConclusionThe data presented in our study suggest that night work may be a risk factor for dementia. More prospective studies with objective exposure measurements are required to further confirm this result.Systematic review registrationhttps://doi.org/10.37766/inplasy2022.6.0079, identifier: INPLASY202260079.https://www.frontiersin.org/articles/10.3389/fneur.2022.997181/fullshift worknight workdementiarisk factorsystematic evaluationmeta-analysis |
| spellingShingle | Zhen-Zhi Wang Zhen Sun Mei-Ling Zhang Kang Xiong Feng Zhou Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysis Frontiers in Neurology shift work night work dementia risk factor systematic evaluation meta-analysis |
| title | Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysis |
| title_full | Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysis |
| title_fullStr | Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysis |
| title_full_unstemmed | Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysis |
| title_short | Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysis |
| title_sort | relationship between shift work night work and subsequent dementia a systematic evaluation and meta analysis |
| topic | shift work night work dementia risk factor systematic evaluation meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.997181/full |
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