Relationship between Soil-Transmitted Helminths Infection and Insulin Sensitivity in Adults at Padang City
Helminth infections in Indonesia are most often caused by Soil-transmitted Helminths (STH) species. It turns out that STH infection has a protective effect against metabolic diseases by affecting glucose metabolism and insulin sensitivity. The effect related to the immune response that caused by STH...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of Jember, Faculty of Medicine
2021-06-01
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| Series: | Journal of Agromedicine and Medical Sciences (AMS) |
| Online Access: | https://jurnal.unej.ac.id/index.php/JAMS/article/view/24117 |
| _version_ | 1811173085370384384 |
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| author | Sitti Monica Astrilia Ambon Nuzulia Irawati Almurdi Almurdi |
| author_facet | Sitti Monica Astrilia Ambon Nuzulia Irawati Almurdi Almurdi |
| author_sort | Sitti Monica Astrilia Ambon |
| collection | DOAJ |
| description | Helminth infections in Indonesia are most often caused by Soil-transmitted Helminths (STH) species. It turns out that STH infection has a protective effect against metabolic diseases by affecting glucose metabolism and insulin sensitivity. The effect related to the immune response that caused by STH infection. The aim of this study was to investigate the relationship between STH infection with insulin sensitivity in adults at Padang City. This study design was a comparative cross-sectional study with multistage random sampling technique. Stool samples were taken from 127 adults and there were 24 subjects (18.9%) infected with STH. Furthermore, We took another 24 uninfected subjects and compared their fasting blood glucose (FBG) and fasting insulin. Then, from the data We calculated it’s Homeostatic Model for Insulin Resistance (HOMA-IR) score to assess insulin sensitivity. Unpaired T test and chi-square were used to analyze the data. The study result showed the average levels of FBG and fasting insulin were lower in STH-infected group than STH-uninfected group. However, there was no significant difference between two groups (FBG p=0.678; fasting insulin p=0.075). Also, STH-infected group tend to had good insulin sensitivity (66.7%) than STH-uninfected group (45.8%), but statistically, there was no significant relationship between STH infection and insulin sensitivity with p value=0.244. In conclusion, there is no relationship between STH infection and insulin sensitivity.
Keywords: Soil-transmitted Helminths, Insulin Sensitivity, FBG |
| first_indexed | 2024-04-10T17:40:56Z |
| format | Article |
| id | doaj.art-4882172aaa8b4203862a933591f490b9 |
| institution | Directory Open Access Journal |
| issn | 2460-9048 2714-5654 |
| language | English |
| last_indexed | 2024-04-10T17:40:56Z |
| publishDate | 2021-06-01 |
| publisher | University of Jember, Faculty of Medicine |
| record_format | Article |
| series | Journal of Agromedicine and Medical Sciences (AMS) |
| spelling | doaj.art-4882172aaa8b4203862a933591f490b92023-02-03T12:23:54ZengUniversity of Jember, Faculty of MedicineJournal of Agromedicine and Medical Sciences (AMS)2460-90482714-56542021-06-0172848810.19184/ams.v7i2.2411724117Relationship between Soil-Transmitted Helminths Infection and Insulin Sensitivity in Adults at Padang CitySitti Monica Astrilia Ambon0Nuzulia Irawati1Almurdi Almurdi2Magister of Biomedical Study Programs, Faculty of Medicine, Andalas University, Padang, IndonesiaDepartment of Parasitology, Faculty of Medicine, Andalas University, Padang, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine, Andalas University, Padang, IndonesiaHelminth infections in Indonesia are most often caused by Soil-transmitted Helminths (STH) species. It turns out that STH infection has a protective effect against metabolic diseases by affecting glucose metabolism and insulin sensitivity. The effect related to the immune response that caused by STH infection. The aim of this study was to investigate the relationship between STH infection with insulin sensitivity in adults at Padang City. This study design was a comparative cross-sectional study with multistage random sampling technique. Stool samples were taken from 127 adults and there were 24 subjects (18.9%) infected with STH. Furthermore, We took another 24 uninfected subjects and compared their fasting blood glucose (FBG) and fasting insulin. Then, from the data We calculated it’s Homeostatic Model for Insulin Resistance (HOMA-IR) score to assess insulin sensitivity. Unpaired T test and chi-square were used to analyze the data. The study result showed the average levels of FBG and fasting insulin were lower in STH-infected group than STH-uninfected group. However, there was no significant difference between two groups (FBG p=0.678; fasting insulin p=0.075). Also, STH-infected group tend to had good insulin sensitivity (66.7%) than STH-uninfected group (45.8%), but statistically, there was no significant relationship between STH infection and insulin sensitivity with p value=0.244. In conclusion, there is no relationship between STH infection and insulin sensitivity. Keywords: Soil-transmitted Helminths, Insulin Sensitivity, FBGhttps://jurnal.unej.ac.id/index.php/JAMS/article/view/24117 |
| spellingShingle | Sitti Monica Astrilia Ambon Nuzulia Irawati Almurdi Almurdi Relationship between Soil-Transmitted Helminths Infection and Insulin Sensitivity in Adults at Padang City Journal of Agromedicine and Medical Sciences (AMS) |
| title | Relationship between Soil-Transmitted Helminths Infection and Insulin Sensitivity in Adults at Padang City |
| title_full | Relationship between Soil-Transmitted Helminths Infection and Insulin Sensitivity in Adults at Padang City |
| title_fullStr | Relationship between Soil-Transmitted Helminths Infection and Insulin Sensitivity in Adults at Padang City |
| title_full_unstemmed | Relationship between Soil-Transmitted Helminths Infection and Insulin Sensitivity in Adults at Padang City |
| title_short | Relationship between Soil-Transmitted Helminths Infection and Insulin Sensitivity in Adults at Padang City |
| title_sort | relationship between soil transmitted helminths infection and insulin sensitivity in adults at padang city |
| url | https://jurnal.unej.ac.id/index.php/JAMS/article/view/24117 |
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