Comparison of admission random glucose, fasting glucose, and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke: a retrospective study
Background Hyperglycemia is a known predictor of negative outcomes in stroke. Several glycemic measures, including admission random glucose, fasting glucose, and glycated hemoglobin (HbA1c), have been associated with bad neurological outcomes in acute ischemic stroke, particularly in nondiabetic pat...
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PeerJ Inc.
2017-02-01
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| Online Access: | https://peerj.com/articles/2948.pdf |
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| author | Jia-Ying Sung Chin-I Chen Yi-Chen Hsieh Yih-Ru Chen Hsin-Chiao Wu Lung Chan Chaur-Jong Hu Han-Hwa Hu Hung-Yi Chiou Nai-Fang Chi |
| author_facet | Jia-Ying Sung Chin-I Chen Yi-Chen Hsieh Yih-Ru Chen Hsin-Chiao Wu Lung Chan Chaur-Jong Hu Han-Hwa Hu Hung-Yi Chiou Nai-Fang Chi |
| author_sort | Jia-Ying Sung |
| collection | DOAJ |
| description | Background Hyperglycemia is a known predictor of negative outcomes in stroke. Several glycemic measures, including admission random glucose, fasting glucose, and glycated hemoglobin (HbA1c), have been associated with bad neurological outcomes in acute ischemic stroke, particularly in nondiabetic patients. However, the predictive power of these glycemic measures is yet to be investigated. Methods This retrospective study enrolled 484 patients with acute ischemic stroke from January 2009 to March 2013, and complete records of initial stroke severity, neurological outcomes at three months, and glycemic measures were evaluated. We examined the predictive power of admission random glucose, fasting glucose, and HbA1c for neurological outcomes in acute ischemic stroke. Furthermore, subgroup analyses of nondiabetic patients and patients with diabetes were performed separately. Results Receiver operating characteristic (ROC) analysis revealed that admission random glucose and fasting glucose were significant predictors of poor neurological outcomes, whereas HbA1c was not (areas under the ROC curve (AUCs): admission random glucose = 0.564, p = 0.026; fasting glucose = 0.598, p = 0.001; HbA1c = 0.510, p = 0.742). Subgroup analyses of nondiabetic patients and those with diabetes revealed that only fasting glucose predicts neurological outcomes in patients with diabetes, and the AUCs of these three glycemic measures did not differ between the two groups. A multivariate logistic regression analysis of the study patients indicated that only age, initial stroke severity, and fasting glucose were independent predictors of poor neurological outcomes, whereas admission random glucose and HbA1c were not (adjusted odds ratio: admission random glucose = 1.002, p = 0.228; fasting glucose = 1.005, p = 0.039; HbA1c = 1.160, p = 0.076). Furthermore, subgroup multivariate logistic regression analyses of nondiabetic patients and those with diabetes indicated that none of the three glycemic measures were associated with poor neurological outcomes. Discussion Fasting glucose is an independent predictor of poor neurological outcomes in patients with acute ischemic stroke and had greater predictive power than that of admission random glucose and HbA1c. The predictive power of glycemic measures for poor neurological outcomes did not differ significantly between the nondiabetic patients and those with diabetes. |
| first_indexed | 2024-03-09T08:00:25Z |
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| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:00:25Z |
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| spelling | doaj.art-4882b02169c448dab0637b72da7f12452023-12-03T00:46:58ZengPeerJ Inc.PeerJ2167-83592017-02-015e294810.7717/peerj.2948Comparison of admission random glucose, fasting glucose, and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke: a retrospective studyJia-Ying Sung0Chin-I Chen1Yi-Chen Hsieh2Yih-Ru Chen3Hsin-Chiao Wu4Lung Chan5Chaur-Jong Hu6Han-Hwa Hu7Hung-Yi Chiou8Nai-Fang Chi9Department of Neurology, Wanfang Hospital, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, Wanfang Hospital, Taipei Medical University, Taipei, TaiwanThe PhD Program of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, TaiwanSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, TaiwanSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanBackground Hyperglycemia is a known predictor of negative outcomes in stroke. Several glycemic measures, including admission random glucose, fasting glucose, and glycated hemoglobin (HbA1c), have been associated with bad neurological outcomes in acute ischemic stroke, particularly in nondiabetic patients. However, the predictive power of these glycemic measures is yet to be investigated. Methods This retrospective study enrolled 484 patients with acute ischemic stroke from January 2009 to March 2013, and complete records of initial stroke severity, neurological outcomes at three months, and glycemic measures were evaluated. We examined the predictive power of admission random glucose, fasting glucose, and HbA1c for neurological outcomes in acute ischemic stroke. Furthermore, subgroup analyses of nondiabetic patients and patients with diabetes were performed separately. Results Receiver operating characteristic (ROC) analysis revealed that admission random glucose and fasting glucose were significant predictors of poor neurological outcomes, whereas HbA1c was not (areas under the ROC curve (AUCs): admission random glucose = 0.564, p = 0.026; fasting glucose = 0.598, p = 0.001; HbA1c = 0.510, p = 0.742). Subgroup analyses of nondiabetic patients and those with diabetes revealed that only fasting glucose predicts neurological outcomes in patients with diabetes, and the AUCs of these three glycemic measures did not differ between the two groups. A multivariate logistic regression analysis of the study patients indicated that only age, initial stroke severity, and fasting glucose were independent predictors of poor neurological outcomes, whereas admission random glucose and HbA1c were not (adjusted odds ratio: admission random glucose = 1.002, p = 0.228; fasting glucose = 1.005, p = 0.039; HbA1c = 1.160, p = 0.076). Furthermore, subgroup multivariate logistic regression analyses of nondiabetic patients and those with diabetes indicated that none of the three glycemic measures were associated with poor neurological outcomes. Discussion Fasting glucose is an independent predictor of poor neurological outcomes in patients with acute ischemic stroke and had greater predictive power than that of admission random glucose and HbA1c. The predictive power of glycemic measures for poor neurological outcomes did not differ significantly between the nondiabetic patients and those with diabetes.https://peerj.com/articles/2948.pdfHyperglycemiaNeurological outcomeAcute ischemic stroke |
| spellingShingle | Jia-Ying Sung Chin-I Chen Yi-Chen Hsieh Yih-Ru Chen Hsin-Chiao Wu Lung Chan Chaur-Jong Hu Han-Hwa Hu Hung-Yi Chiou Nai-Fang Chi Comparison of admission random glucose, fasting glucose, and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke: a retrospective study PeerJ Hyperglycemia Neurological outcome Acute ischemic stroke |
| title | Comparison of admission random glucose, fasting glucose, and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke: a retrospective study |
| title_full | Comparison of admission random glucose, fasting glucose, and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke: a retrospective study |
| title_fullStr | Comparison of admission random glucose, fasting glucose, and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke: a retrospective study |
| title_full_unstemmed | Comparison of admission random glucose, fasting glucose, and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke: a retrospective study |
| title_short | Comparison of admission random glucose, fasting glucose, and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke: a retrospective study |
| title_sort | comparison of admission random glucose fasting glucose and glycated hemoglobin in predicting the neurological outcome of acute ischemic stroke a retrospective study |
| topic | Hyperglycemia Neurological outcome Acute ischemic stroke |
| url | https://peerj.com/articles/2948.pdf |
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