Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs

Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs

Abstract There is a clinical need for conceptually new treatments that target the excessive activation of inflammatory pathways during systemic infection. Thrombin-derived C-terminal peptides (TCPs) are endogenous anti-infective immunomodulators interfering with CD14-mediated TLR-dependent immune re...

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Bibliographic Details
Main Authors: Ganna Petruk, Manoj Puthia, Firdaus Samsudin, Jitka Petrlova, Franziska Olm, Margareta Mittendorfer, Snejana Hyllén, Dag Edström, Ann-Charlotte Strömdahl, Carl Diehl, Simon Ekström, Björn Walse, Sven Kjellström, Peter J. Bond, Sandra Lindstedt, Artur Schmidtchen
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41702-y

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