TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model

TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model

Abstract Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans. Increased levels of tumor necrosis factor-α (TNF-α) and tr...

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Main Authors: Yuji Yokozeki, Kentaro Uchida, Ayumu Kawakubo, Mitsufumi Nakawaki, Tadashi Okubo, Masayuki Miyagi, Gen Inoue, Makoto Itakura, Hiroyuki Sekiguchi, Masashi Takaso
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Musculoskeletal Disorders
Subjects:
Transforming growth factor-β
Nerve growth factor
Intervertebral disc
Online Access:https://doi.org/10.1186/s12891-021-04509-w

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