CERVICAL INTRAEPITHELIAL NEOPLASIA TREATMENT. ANALYSIS OF THE DATA OF THE PATIENTS TREATED AT DEPARTMENT OF GYNECOLOGY AND OBSTETRICS IN LJUBLJANA DURING 1996–2000
<p>Background. Successful diagnosis and management of cervical intraepithelial neoplasia (CIN) prevent the occurrence of invasive cervical cancer, which is one of the important indicators of the national health care.</p><p>Methods. The retrospective analysis studies patients at Dep...
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| Format: | Article |
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Slovenian Medical Association
2003-12-01
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| Series: | Zdravniški Vestnik |
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| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/2217 |
| _version_ | 1818066232550621184 |
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| author | Mili Lomšek Stelio Rakar Borut Kobal |
| author_facet | Mili Lomšek Stelio Rakar Borut Kobal |
| author_sort | Mili Lomšek |
| collection | DOAJ |
| description | <p>Background. Successful diagnosis and management of cervical intraepithelial neoplasia (CIN) prevent the occurrence of invasive cervical cancer, which is one of the important indicators of the national health care.</p><p>Methods. The retrospective analysis studies patients at Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, who had in the period from January 1996 to December 2000 cervical biopsy due to CIN suspicion, based on abnormal PAP smear test and/or abnormal colposcopy. The patients, whose CIN diagnosis was confirmed with cervical biopsy sample histology, were treated by local methods (laser vaporisation, laser conization, large loop excision of the transformation zone (LLETZ), cold-knife conization), hysterectomy or just supervised with 4–6 month PAP smear and colposcopy follow-up. Our efficiency criteria were PAP smear one year after the treatment and excised tissue histology (for local excision methods and hysterectomy). We also compared the histology of the cervical biopsy sample and the excised tissue after excision methods of treatment and hysterectomy. The sources of our database were the patients’ records.</p><p>Results. The study analyses 800 patients. In 195 women (24%) CIN wasn’t confirmed by cervical biopsy sample histology. In the remaining 605 patients (76%), we diagnosed severe dysplasia (CIN III) in 332 women (55%), moderate dysplasia (CIN II) in 153 women (25%) and light dysplasia (CIN I) in 120 women (20%). CIN was most frequently diagnosed in the age between 30 and 34. CIN III was most frequently treated with cold-knife conization and CIN II with laser vaporisation. We also treated 120 patients (66%) with CIN I, mostly with laser vaporisation. There were no substantive differences in therapeutic efficacy between the methods of treatment. Besides hysterectomy, the most successful method was cold-knife conization in 96,9%, and the least successful LLETZ in 91,7%. The histology between cervical biopsy sample and excised tissue after local excision methods and hysterectomy matched in 75%.</p><p>Conclusions. Considering known criteria we find local conservative methods of CIN treatment successful and having advantage compared to the other methods of CIN treatment.</p> |
| first_indexed | 2024-12-10T15:04:31Z |
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| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-12-10T15:04:31Z |
| publishDate | 2003-12-01 |
| publisher | Slovenian Medical Association |
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| spelling | doaj.art-488457c40cc14efa9792322298c69cd32022-12-22T01:44:06ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242003-12-017201697CERVICAL INTRAEPITHELIAL NEOPLASIA TREATMENT. ANALYSIS OF THE DATA OF THE PATIENTS TREATED AT DEPARTMENT OF GYNECOLOGY AND OBSTETRICS IN LJUBLJANA DURING 1996–2000Mili Lomšek0Stelio Rakar1Borut Kobal2Splošna bolnišnica Trbovlje Rudarska c. 9 1420 TrbovljeGinekološka klinika Klinični center Šlajmerjeva 3 1525 LjubljanaGinekološka klinika Klinični center Šlajmerjeva 3 1525 Ljubljana<p>Background. Successful diagnosis and management of cervical intraepithelial neoplasia (CIN) prevent the occurrence of invasive cervical cancer, which is one of the important indicators of the national health care.</p><p>Methods. The retrospective analysis studies patients at Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, who had in the period from January 1996 to December 2000 cervical biopsy due to CIN suspicion, based on abnormal PAP smear test and/or abnormal colposcopy. The patients, whose CIN diagnosis was confirmed with cervical biopsy sample histology, were treated by local methods (laser vaporisation, laser conization, large loop excision of the transformation zone (LLETZ), cold-knife conization), hysterectomy or just supervised with 4–6 month PAP smear and colposcopy follow-up. Our efficiency criteria were PAP smear one year after the treatment and excised tissue histology (for local excision methods and hysterectomy). We also compared the histology of the cervical biopsy sample and the excised tissue after excision methods of treatment and hysterectomy. The sources of our database were the patients’ records.</p><p>Results. The study analyses 800 patients. In 195 women (24%) CIN wasn’t confirmed by cervical biopsy sample histology. In the remaining 605 patients (76%), we diagnosed severe dysplasia (CIN III) in 332 women (55%), moderate dysplasia (CIN II) in 153 women (25%) and light dysplasia (CIN I) in 120 women (20%). CIN was most frequently diagnosed in the age between 30 and 34. CIN III was most frequently treated with cold-knife conization and CIN II with laser vaporisation. We also treated 120 patients (66%) with CIN I, mostly with laser vaporisation. There were no substantive differences in therapeutic efficacy between the methods of treatment. Besides hysterectomy, the most successful method was cold-knife conization in 96,9%, and the least successful LLETZ in 91,7%. The histology between cervical biopsy sample and excised tissue after local excision methods and hysterectomy matched in 75%.</p><p>Conclusions. Considering known criteria we find local conservative methods of CIN treatment successful and having advantage compared to the other methods of CIN treatment.</p>http://vestnik.szd.si/index.php/ZdravVest/article/view/2217cervical intraepithelial neoplasiamethods of treatment |
| spellingShingle | Mili Lomšek Stelio Rakar Borut Kobal CERVICAL INTRAEPITHELIAL NEOPLASIA TREATMENT. ANALYSIS OF THE DATA OF THE PATIENTS TREATED AT DEPARTMENT OF GYNECOLOGY AND OBSTETRICS IN LJUBLJANA DURING 1996–2000 Zdravniški Vestnik cervical intraepithelial neoplasia methods of treatment |
| title | CERVICAL INTRAEPITHELIAL NEOPLASIA TREATMENT. ANALYSIS OF THE DATA OF THE PATIENTS TREATED AT DEPARTMENT OF GYNECOLOGY AND OBSTETRICS IN LJUBLJANA DURING 1996–2000 |
| title_full | CERVICAL INTRAEPITHELIAL NEOPLASIA TREATMENT. ANALYSIS OF THE DATA OF THE PATIENTS TREATED AT DEPARTMENT OF GYNECOLOGY AND OBSTETRICS IN LJUBLJANA DURING 1996–2000 |
| title_fullStr | CERVICAL INTRAEPITHELIAL NEOPLASIA TREATMENT. ANALYSIS OF THE DATA OF THE PATIENTS TREATED AT DEPARTMENT OF GYNECOLOGY AND OBSTETRICS IN LJUBLJANA DURING 1996–2000 |
| title_full_unstemmed | CERVICAL INTRAEPITHELIAL NEOPLASIA TREATMENT. ANALYSIS OF THE DATA OF THE PATIENTS TREATED AT DEPARTMENT OF GYNECOLOGY AND OBSTETRICS IN LJUBLJANA DURING 1996–2000 |
| title_short | CERVICAL INTRAEPITHELIAL NEOPLASIA TREATMENT. ANALYSIS OF THE DATA OF THE PATIENTS TREATED AT DEPARTMENT OF GYNECOLOGY AND OBSTETRICS IN LJUBLJANA DURING 1996–2000 |
| title_sort | cervical intraepithelial neoplasia treatment analysis of the data of the patients treated at department of gynecology and obstetrics in ljubljana during 1996 2000 |
| topic | cervical intraepithelial neoplasia methods of treatment |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/2217 |
| work_keys_str_mv | AT mililomsek cervicalintraepithelialneoplasiatreatmentanalysisofthedataofthepatientstreatedatdepartmentofgynecologyandobstetricsinljubljanaduring19962000 AT steliorakar cervicalintraepithelialneoplasiatreatmentanalysisofthedataofthepatientstreatedatdepartmentofgynecologyandobstetricsinljubljanaduring19962000 AT borutkobal cervicalintraepithelialneoplasiatreatmentanalysisofthedataofthepatientstreatedatdepartmentofgynecologyandobstetricsinljubljanaduring19962000 |