Safety, efficacy and prognosis of anticoagulant therapy for portal vein thrombosis in cirrhosis: a retrospective cohort study
Abstract Background The role of anticoagulants in the treatment of cirrhotic PVT remains controversial. This study aimed to analyze the safety and efficacy of anticoagulant therapy in patients with cirrhotic portal vein thrombosis (PVT) and its impact on prognosis. Methods A retrospective cohort stu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12959-023-00454-x |
| _version_ | 1811171559222542336 |
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| author | Zhiqi Zhang Ying Zhao Dandan Li Mingxing Guo Hongyu Li Ranjia Liu Xiangli Cui |
| author_facet | Zhiqi Zhang Ying Zhao Dandan Li Mingxing Guo Hongyu Li Ranjia Liu Xiangli Cui |
| author_sort | Zhiqi Zhang |
| collection | DOAJ |
| description | Abstract Background The role of anticoagulants in the treatment of cirrhotic PVT remains controversial. This study aimed to analyze the safety and efficacy of anticoagulant therapy in patients with cirrhotic portal vein thrombosis (PVT) and its impact on prognosis. Methods A retrospective cohort study was conducted for PVT patients with liver cirrhosis in our hospital. The primary outcome of the study was the PVT recanalization rate. Other outcomes included bleeding rate, liver function, and mortality. Cox and Logistic regression were used to explore the risk factors of outcomes. Results This study included 77 patients that 27 patients in the anticoagulant group and 50 in the non-anticoagulant group. Anticoagulant therapy was associated with higher rate of PVT recanalization (44.4% vs 20.0%, log-rank P = 0.016) and lower rate of PVT progression (7.4% vs 30.0%, log-rank P = 0.026), and without increasing the rate of total bleeding (14.8% vs 24%, P = 0.343), major bleeding (3.7% vs 6%, P = 0.665) and variceal bleeding (3.7% vs 16%, P = 0.109). The safety and efficacy of different anticoagulants were similar. The Child-Pugh grade of the anticoagulant therapy group was better than that of the non-anticoagulant therapy group (P = 0.030). There was no significant difference in the 2-year survival rate of the two groups. Conclusion Anticoagulants could increase the PVT recanalization rate and reduce the PVT progression rate without increasing the rate of bleeding. Anticoagulants may be beneficial to improving the liver function of patients with cirrhotic PVT. There was no significant difference in the safety and efficacy of different anticoagulants in the treatment of cirrhotic PVT. |
| first_indexed | 2024-04-10T17:16:01Z |
| format | Article |
| id | doaj.art-48849c0afa2d4c62984d796f0f0437ba |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-04-10T17:16:01Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-48849c0afa2d4c62984d796f0f0437ba2023-02-05T12:21:13ZengBMCThrombosis Journal1477-95602023-01-012111810.1186/s12959-023-00454-xSafety, efficacy and prognosis of anticoagulant therapy for portal vein thrombosis in cirrhosis: a retrospective cohort studyZhiqi Zhang0Ying Zhao1Dandan Li2Mingxing Guo3Hongyu Li4Ranjia Liu5Xiangli Cui6Department of Pharmacy, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical UniversityLiver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical UniversityAbstract Background The role of anticoagulants in the treatment of cirrhotic PVT remains controversial. This study aimed to analyze the safety and efficacy of anticoagulant therapy in patients with cirrhotic portal vein thrombosis (PVT) and its impact on prognosis. Methods A retrospective cohort study was conducted for PVT patients with liver cirrhosis in our hospital. The primary outcome of the study was the PVT recanalization rate. Other outcomes included bleeding rate, liver function, and mortality. Cox and Logistic regression were used to explore the risk factors of outcomes. Results This study included 77 patients that 27 patients in the anticoagulant group and 50 in the non-anticoagulant group. Anticoagulant therapy was associated with higher rate of PVT recanalization (44.4% vs 20.0%, log-rank P = 0.016) and lower rate of PVT progression (7.4% vs 30.0%, log-rank P = 0.026), and without increasing the rate of total bleeding (14.8% vs 24%, P = 0.343), major bleeding (3.7% vs 6%, P = 0.665) and variceal bleeding (3.7% vs 16%, P = 0.109). The safety and efficacy of different anticoagulants were similar. The Child-Pugh grade of the anticoagulant therapy group was better than that of the non-anticoagulant therapy group (P = 0.030). There was no significant difference in the 2-year survival rate of the two groups. Conclusion Anticoagulants could increase the PVT recanalization rate and reduce the PVT progression rate without increasing the rate of bleeding. Anticoagulants may be beneficial to improving the liver function of patients with cirrhotic PVT. There was no significant difference in the safety and efficacy of different anticoagulants in the treatment of cirrhotic PVT.https://doi.org/10.1186/s12959-023-00454-xAnticoagulantPortal vein thrombosisLiver cirrhosis |
| spellingShingle | Zhiqi Zhang Ying Zhao Dandan Li Mingxing Guo Hongyu Li Ranjia Liu Xiangli Cui Safety, efficacy and prognosis of anticoagulant therapy for portal vein thrombosis in cirrhosis: a retrospective cohort study Thrombosis Journal Anticoagulant Portal vein thrombosis Liver cirrhosis |
| title | Safety, efficacy and prognosis of anticoagulant therapy for portal vein thrombosis in cirrhosis: a retrospective cohort study |
| title_full | Safety, efficacy and prognosis of anticoagulant therapy for portal vein thrombosis in cirrhosis: a retrospective cohort study |
| title_fullStr | Safety, efficacy and prognosis of anticoagulant therapy for portal vein thrombosis in cirrhosis: a retrospective cohort study |
| title_full_unstemmed | Safety, efficacy and prognosis of anticoagulant therapy for portal vein thrombosis in cirrhosis: a retrospective cohort study |
| title_short | Safety, efficacy and prognosis of anticoagulant therapy for portal vein thrombosis in cirrhosis: a retrospective cohort study |
| title_sort | safety efficacy and prognosis of anticoagulant therapy for portal vein thrombosis in cirrhosis a retrospective cohort study |
| topic | Anticoagulant Portal vein thrombosis Liver cirrhosis |
| url | https://doi.org/10.1186/s12959-023-00454-x |
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