Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum.
Schistosomes are flatworm parasites that undergo a complex life cycle involving two hosts. The regulation of the parasite's developmental processes relies on both coding RNAs and non-coding RNAs. However, the roles of non-coding RNAs, including long non-coding RNAs (lncRNAs) in schistosomes rem...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1011949 |
| _version_ | 1797296200636956672 |
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| author | Shaoyun Cheng Yanmin You Xiaoling Wang Cun Yi Wei Zhang Yuxiang Xie Lei Xiu Fang Luo Yan Lu Jipeng Wang Wei Hu |
| author_facet | Shaoyun Cheng Yanmin You Xiaoling Wang Cun Yi Wei Zhang Yuxiang Xie Lei Xiu Fang Luo Yan Lu Jipeng Wang Wei Hu |
| author_sort | Shaoyun Cheng |
| collection | DOAJ |
| description | Schistosomes are flatworm parasites that undergo a complex life cycle involving two hosts. The regulation of the parasite's developmental processes relies on both coding RNAs and non-coding RNAs. However, the roles of non-coding RNAs, including long non-coding RNAs (lncRNAs) in schistosomes remain largely unexplored. Here we conduct advanced RNA sequencing on male and female S. japonicum during their pairing and reproductive development, resulting in the identification of nearly 8,000 lncRNAs. This extensive dataset enables us to construct a comprehensive co-expression network of lncRNAs and mRNAs, shedding light on their interactions during the crucial reproductive stages within the mammalian host. Importantly, we have also revealed a specific lncRNA, LNC3385, which appears to play a critical role in the survival and reproduction of the parasite. These findings not only enhance our understanding of the dynamic nature of lncRNAs during the reproductive phase of schistosomes but also highlight LNC3385 as a potential therapeutic target for combating schistosomiasis. |
| first_indexed | 2024-03-07T21:59:57Z |
| format | Article |
| id | doaj.art-48856e79c9aa4389a69478002bfce0a1 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-03-07T21:59:57Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-48856e79c9aa4389a69478002bfce0a12024-02-24T05:31:28ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742024-01-01201e101194910.1371/journal.ppat.1011949Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum.Shaoyun ChengYanmin YouXiaoling WangCun YiWei ZhangYuxiang XieLei XiuFang LuoYan LuJipeng WangWei HuSchistosomes are flatworm parasites that undergo a complex life cycle involving two hosts. The regulation of the parasite's developmental processes relies on both coding RNAs and non-coding RNAs. However, the roles of non-coding RNAs, including long non-coding RNAs (lncRNAs) in schistosomes remain largely unexplored. Here we conduct advanced RNA sequencing on male and female S. japonicum during their pairing and reproductive development, resulting in the identification of nearly 8,000 lncRNAs. This extensive dataset enables us to construct a comprehensive co-expression network of lncRNAs and mRNAs, shedding light on their interactions during the crucial reproductive stages within the mammalian host. Importantly, we have also revealed a specific lncRNA, LNC3385, which appears to play a critical role in the survival and reproduction of the parasite. These findings not only enhance our understanding of the dynamic nature of lncRNAs during the reproductive phase of schistosomes but also highlight LNC3385 as a potential therapeutic target for combating schistosomiasis.https://doi.org/10.1371/journal.ppat.1011949 |
| spellingShingle | Shaoyun Cheng Yanmin You Xiaoling Wang Cun Yi Wei Zhang Yuxiang Xie Lei Xiu Fang Luo Yan Lu Jipeng Wang Wei Hu Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum. PLoS Pathogens |
| title | Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum. |
| title_full | Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum. |
| title_fullStr | Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum. |
| title_full_unstemmed | Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum. |
| title_short | Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum. |
| title_sort | dynamic profiles of lncrnas reveal a functional natural antisense rna that regulates the development of schistosoma japonicum |
| url | https://doi.org/10.1371/journal.ppat.1011949 |
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