MERS-CoV Spike Protein Vaccine and Inactivated Influenza Vaccine Formulated with Single Strand RNA Adjuvant Induce T-Cell Activation through Intranasal Immunization in Mice

MERS-CoV Spike Protein Vaccine and Inactivated Influenza Vaccine Formulated with Single Strand RNA Adjuvant Induce T-Cell Activation through Intranasal Immunization in Mice

The effectiveness of vaccines is enhanced by adding adjuvants. Furthermore, the selection of an inoculation route depends on the type of adjuvant used and is important for achieving optimum vaccine efficacy. We investigated the immunological differences between two types of vaccines—spike protein fr...

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Bibliographic Details
Main Authors: Hye-Jung Kim, Hye Won Kwak, Kyung Won Kang, Yoo-Jin Bang, Yu-Sun Lee, Hyeong-Jun Park, Jae-Yong Kim, Hyo-Jung Park, Kyung-Ah Hwang, Sang-Myeong Lee, Jae-Hwan Nam
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
intramuscular immunization
intranasal immunization
RNA adjuvant
protein-based vaccine
inactivated vaccine
Middle East respiratory syndrome coronavirus (MERS-CoA)
Online Access:https://www.mdpi.com/1999-4923/12/5/441

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