Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United KingdomResearch in context
Summary: Background: There is an urgent public health need to evaluate disease severity in adults hospitalised with Delta and Omicron SARS-CoV-2 variant infections. However, limited data exist assessing severity of disease in adults hospitalised with Omicron SARS-CoV-2 infections, and to what exten...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
|
| Series: | The Lancet Regional Health. Europe |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666776222002526 |
| _version_ | 1811177803687657472 |
|---|---|
| author | Catherine Hyams Robert Challen Robin Marlow Jennifer Nguyen Elizabeth Begier Jo Southern Jade King Anna Morley Jane Kinney Madeleine Clout Jennifer Oliver Sharon Gray Gillian Ellsbury Nick Maskell Luis Jodar Bradford Gessner John McLaughlin Leon Danon Adam Finn Anna Morley Amelia Langdon Anabella Turner Anya Mattocks Bethany Osborne Charli Grimes Claire Mitchell David Adegbite Emma Bridgeman Emma Scott Fiona Perkins Francesca Bayley Gabriella Ruffino Gabriella Valentine Grace Tilzey James Campling Johanna Kellett Wright Julia Brzezinska Julie Cloake Katarina Milutinovic Kate Helliker Katie Maughan Kazminder Fox Konstantina Minou Lana Ward Leah Fleming Leigh Morrison Lily Smart Louise Wright Lucy Grimwood Maddalena Bellavia Madeleine Clout Marianne Vasquez Maria Garcia Gonzalez Milo Jeenes-Flanagan Natalie Chang Niall Grace Nicola Manning Oliver Griffiths Pip Croxford Peter Sequenza Rajeka Lazarus Rhian Walters Robin Marlow Robyn Heath Rupert Antico Sandi Nammuni Arachchge Seevakumar Suppiah Taslima Mona Tawassal Riaz Vicki Mackay Zandile Maseko Zoe Taylor Zsolt Friedrich Zsuzsa Szasz-Benczur |
| author_facet | Catherine Hyams Robert Challen Robin Marlow Jennifer Nguyen Elizabeth Begier Jo Southern Jade King Anna Morley Jane Kinney Madeleine Clout Jennifer Oliver Sharon Gray Gillian Ellsbury Nick Maskell Luis Jodar Bradford Gessner John McLaughlin Leon Danon Adam Finn Anna Morley Amelia Langdon Anabella Turner Anya Mattocks Bethany Osborne Charli Grimes Claire Mitchell David Adegbite Emma Bridgeman Emma Scott Fiona Perkins Francesca Bayley Gabriella Ruffino Gabriella Valentine Grace Tilzey James Campling Johanna Kellett Wright Julia Brzezinska Julie Cloake Katarina Milutinovic Kate Helliker Katie Maughan Kazminder Fox Konstantina Minou Lana Ward Leah Fleming Leigh Morrison Lily Smart Louise Wright Lucy Grimwood Maddalena Bellavia Madeleine Clout Marianne Vasquez Maria Garcia Gonzalez Milo Jeenes-Flanagan Natalie Chang Niall Grace Nicola Manning Oliver Griffiths Pip Croxford Peter Sequenza Rajeka Lazarus Rhian Walters Robin Marlow Robyn Heath Rupert Antico Sandi Nammuni Arachchge Seevakumar Suppiah Taslima Mona Tawassal Riaz Vicki Mackay Zandile Maseko Zoe Taylor Zsolt Friedrich Zsuzsa Szasz-Benczur |
| author_sort | Catherine Hyams |
| collection | DOAJ |
| description | Summary: Background: There is an urgent public health need to evaluate disease severity in adults hospitalised with Delta and Omicron SARS-CoV-2 variant infections. However, limited data exist assessing severity of disease in adults hospitalised with Omicron SARS-CoV-2 infections, and to what extent patient-factors, including vaccination, age, frailty and pre-existing disease, affect variant-dependent disease severity. Methods: A prospective cohort study of adults (≥18 years of age) hospitalised with acute lower respiratory tract disease at acute care hospitals in Bristol, UK conducted over 10-months. Delta or Omicron SARS-CoV-2 infection was defined by positive SARS-CoV-2 PCR and variant identification or inferred by dominant circulating variant. We constructed adjusted regression analyses to assess disease severity using three different measures: FiO2 >28% (fraction inspired oxygen), World Health Organization (WHO) outcome score >5 (assessing need for ventilatory support), and hospital length of stay (LOS) >3 days following admission for Omicron or Delta infection. Findings: Independent of other variables, including vaccination, Omicron variant infection in hospitalised adults was associated with lower severity than Delta. Risk reductions were 58%, 67%, and 16% for supplementary oxygen with >28% FiO2 [Relative Risk (RR) = 0.42 (95%CI: 0.34–0.52), P < 0.001], WHO outcome score >5 [RR = 0.33 (95%CI: 0.21–0.50), P < 0.001], and to have had a LOS > 3 days [RR = 0.84 (95%CI: 0.76–0.92), P < 0.001]. Younger age and vaccination with two or three doses were also independently associated with lower COVID-19 severity. Interpretation: We provide reassuring evidence that Omicron infection results in less serious adverse outcomes than Delta in hospitalised patients. Despite lower severity relative to Delta, Omicron infection still resulted in substantial patient and public health burden and an increased admission rate of older patients with Omicron which counteracts some of the benefit arising from less severe disease. Funding: AvonCAP is an investigator-led project funded under a collaborative agreement by Pfizer. |
| first_indexed | 2024-04-11T06:08:30Z |
| format | Article |
| id | doaj.art-48870e4442ed4c979d2bf5a82bb8cc0e |
| institution | Directory Open Access Journal |
| issn | 2666-7762 |
| language | English |
| last_indexed | 2024-04-11T06:08:30Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Europe |
| spelling | doaj.art-48870e4442ed4c979d2bf5a82bb8cc0e2022-12-22T04:41:25ZengElsevierThe Lancet Regional Health. Europe2666-77622023-02-0125100556Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United KingdomResearch in contextCatherine Hyams0Robert Challen1Robin Marlow2Jennifer Nguyen3Elizabeth Begier4Jo Southern5Jade King6Anna Morley7Jane Kinney8Madeleine Clout9Jennifer Oliver10Sharon Gray11Gillian Ellsbury12Nick Maskell13Luis Jodar14Bradford Gessner15John McLaughlin16Leon Danon17Adam Finn18Anna MorleyAmelia LangdonAnabella TurnerAnya MattocksBethany OsborneCharli GrimesClaire MitchellDavid AdegbiteEmma BridgemanEmma ScottFiona PerkinsFrancesca BayleyGabriella RuffinoGabriella ValentineGrace TilzeyJames CamplingJohanna Kellett WrightJulia BrzezinskaJulie CloakeKatarina MilutinovicKate HellikerKatie MaughanKazminder FoxKonstantina MinouLana WardLeah FlemingLeigh MorrisonLily SmartLouise WrightLucy GrimwoodMaddalena BellaviaMadeleine CloutMarianne VasquezMaria Garcia GonzalezMilo Jeenes-FlanaganNatalie ChangNiall GraceNicola ManningOliver GriffithsPip CroxfordPeter SequenzaRajeka LazarusRhian WaltersRobin MarlowRobyn HeathRupert AnticoSandi Nammuni ArachchgeSeevakumar SuppiahTaslima MonaTawassal RiazVicki MackayZandile MasekoZoe TaylorZsolt FriedrichZsuzsa Szasz-BenczurPopulation Health Sciences, University of Bristol, Bristol, UK; Bristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UKBristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UK; Engineering Mathematics, University of Bristol, Bristol, UKPopulation Health Sciences, University of Bristol, Bristol, UKVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccine and Testing Team, Clinical Research Facility, UHBW NHS Trust, Bristol, UKAcademic Respiratory Unit, University of Bristol, Southmead Hospital, Bristol, UKBristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UKBristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UKBristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UKVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAAcademic Respiratory Unit, University of Bristol, Southmead Hospital, Bristol, UKVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USABristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UK; Engineering Mathematics, University of Bristol, Bristol, UKPopulation Health Sciences, University of Bristol, Bristol, UK; Bristol Vaccine Centre, Population Health Sciences, University of Bristol, Bristol, UK; Corresponding author. Bristol Vaccine Centre, University of Bristol, Level 6, UHB Education and Research Centre, Upper Maudlin Street, Bristol BS2 8AE, UK.Summary: Background: There is an urgent public health need to evaluate disease severity in adults hospitalised with Delta and Omicron SARS-CoV-2 variant infections. However, limited data exist assessing severity of disease in adults hospitalised with Omicron SARS-CoV-2 infections, and to what extent patient-factors, including vaccination, age, frailty and pre-existing disease, affect variant-dependent disease severity. Methods: A prospective cohort study of adults (≥18 years of age) hospitalised with acute lower respiratory tract disease at acute care hospitals in Bristol, UK conducted over 10-months. Delta or Omicron SARS-CoV-2 infection was defined by positive SARS-CoV-2 PCR and variant identification or inferred by dominant circulating variant. We constructed adjusted regression analyses to assess disease severity using three different measures: FiO2 >28% (fraction inspired oxygen), World Health Organization (WHO) outcome score >5 (assessing need for ventilatory support), and hospital length of stay (LOS) >3 days following admission for Omicron or Delta infection. Findings: Independent of other variables, including vaccination, Omicron variant infection in hospitalised adults was associated with lower severity than Delta. Risk reductions were 58%, 67%, and 16% for supplementary oxygen with >28% FiO2 [Relative Risk (RR) = 0.42 (95%CI: 0.34–0.52), P < 0.001], WHO outcome score >5 [RR = 0.33 (95%CI: 0.21–0.50), P < 0.001], and to have had a LOS > 3 days [RR = 0.84 (95%CI: 0.76–0.92), P < 0.001]. Younger age and vaccination with two or three doses were also independently associated with lower COVID-19 severity. Interpretation: We provide reassuring evidence that Omicron infection results in less serious adverse outcomes than Delta in hospitalised patients. Despite lower severity relative to Delta, Omicron infection still resulted in substantial patient and public health burden and an increased admission rate of older patients with Omicron which counteracts some of the benefit arising from less severe disease. Funding: AvonCAP is an investigator-led project funded under a collaborative agreement by Pfizer.http://www.sciencedirect.com/science/article/pii/S2666776222002526COVID-19SARS-CoV-2Respiratory infectionVaccination |
| spellingShingle | Catherine Hyams Robert Challen Robin Marlow Jennifer Nguyen Elizabeth Begier Jo Southern Jade King Anna Morley Jane Kinney Madeleine Clout Jennifer Oliver Sharon Gray Gillian Ellsbury Nick Maskell Luis Jodar Bradford Gessner John McLaughlin Leon Danon Adam Finn Anna Morley Amelia Langdon Anabella Turner Anya Mattocks Bethany Osborne Charli Grimes Claire Mitchell David Adegbite Emma Bridgeman Emma Scott Fiona Perkins Francesca Bayley Gabriella Ruffino Gabriella Valentine Grace Tilzey James Campling Johanna Kellett Wright Julia Brzezinska Julie Cloake Katarina Milutinovic Kate Helliker Katie Maughan Kazminder Fox Konstantina Minou Lana Ward Leah Fleming Leigh Morrison Lily Smart Louise Wright Lucy Grimwood Maddalena Bellavia Madeleine Clout Marianne Vasquez Maria Garcia Gonzalez Milo Jeenes-Flanagan Natalie Chang Niall Grace Nicola Manning Oliver Griffiths Pip Croxford Peter Sequenza Rajeka Lazarus Rhian Walters Robin Marlow Robyn Heath Rupert Antico Sandi Nammuni Arachchge Seevakumar Suppiah Taslima Mona Tawassal Riaz Vicki Mackay Zandile Maseko Zoe Taylor Zsolt Friedrich Zsuzsa Szasz-Benczur Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United KingdomResearch in context The Lancet Regional Health. Europe COVID-19 SARS-CoV-2 Respiratory infection Vaccination |
| title | Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United KingdomResearch in context |
| title_full | Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United KingdomResearch in context |
| title_fullStr | Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United KingdomResearch in context |
| title_full_unstemmed | Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United KingdomResearch in context |
| title_short | Severity of Omicron (B.1.1.529) and Delta (B.1.617.2) SARS-CoV-2 infection among hospitalised adults: A prospective cohort study in Bristol, United KingdomResearch in context |
| title_sort | severity of omicron b 1 1 529 and delta b 1 617 2 sars cov 2 infection among hospitalised adults a prospective cohort study in bristol united kingdomresearch in context |
| topic | COVID-19 SARS-CoV-2 Respiratory infection Vaccination |
| url | http://www.sciencedirect.com/science/article/pii/S2666776222002526 |
| work_keys_str_mv | AT catherinehyams severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT robertchallen severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT robinmarlow severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT jennifernguyen severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT elizabethbegier severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT josouthern severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT jadeking severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT annamorley severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT janekinney severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT madeleineclout severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT jenniferoliver severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT sharongray severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT gillianellsbury severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT nickmaskell severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT luisjodar severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT bradfordgessner severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT johnmclaughlin severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT leondanon severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT adamfinn severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT annamorley severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT amelialangdon severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT anabellaturner severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT anyamattocks severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT bethanyosborne severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT charligrimes severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT clairemitchell severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT davidadegbite severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT emmabridgeman severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT emmascott severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT fionaperkins severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT francescabayley severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT gabriellaruffino severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT gabriellavalentine severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT gracetilzey severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT jamescampling severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT johannakellettwright severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT juliabrzezinska severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT juliecloake severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT katarinamilutinovic severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT katehelliker severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT katiemaughan severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT kazminderfox severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT konstantinaminou severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT lanaward severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT leahfleming severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT leighmorrison severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT lilysmart severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT louisewright severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT lucygrimwood severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT maddalenabellavia severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT madeleineclout severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT mariannevasquez severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT mariagarciagonzalez severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT milojeenesflanagan severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT nataliechang severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT niallgrace severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT nicolamanning severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT olivergriffiths severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT pipcroxford severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT petersequenza severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT rajekalazarus severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT rhianwalters severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT robinmarlow severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT robynheath severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT rupertantico severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT sandinammuniarachchge severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT seevakumarsuppiah severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT taslimamona severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT tawassalriaz severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT vickimackay severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT zandilemaseko severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT zoetaylor severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT zsoltfriedrich severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext AT zsuzsaszaszbenczur severityofomicronb11529anddeltab16172sarscov2infectionamonghospitalisedadultsaprospectivecohortstudyinbristolunitedkingdomresearchincontext |